Evidence map›Paper›PMID 30886381›Full record

ArticleScientific reports2019

Characterisation of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of Photodynamic Therapy.

Silvia Rocio Lucena, Alicia Zamarrón, Elisa Carrasco, Miguel Angel Marigil, Marta Mascaraque, Montserrat Fernández-Guarino, Yolanda Gilaberte, Salvador González, Angeles Juarranz

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Silvia Rocio LucenaBiology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.
Alicia ZamarrónBiology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.
Elisa CarrascoMolecular Biology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.ORCID 0000-0002-0817-1627
Miguel Angel MarigilPathology Service, Hospital San Jorge, Huesca, Spain.
Marta MascaraqueBiology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain.
Montserrat Fernández-GuarinoDermatology Service, Hospital Ramón y Cajal, Madrid, Spain.
Yolanda GilaberteDermatology Service, Hospital Miguel Servet, Zaragoza, Spain.
Salvador GonzálezMedicine and Medical Specialties Department, Alcalá de Henares University, Madrid, Spain.
Angeles JuarranzBiology Department, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain. angeles.juarranz@uam.es.
Universidad Autónoma de Madrid · ESHospital General San Jorge · ESHospital Universitario Miguel Servet · ESHospital Universitario Ramón y Cajal · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic Therapy (PDT) with methyl-aminolevulinate acid (MAL-PDT) is being used for the treatment of Basal cell carcinoma (BCC), but recurrences have been reported. In this work, we have evaluated resistance mechanisms to MAL-PDT developed by three BCC cell lines (ASZ, BSZ and CSZ), derived from mice on a ptch+/- background and with or without p53 expression, subjected to 10 cycles of PDT (10

Indexed as

Aminolevulinic AcidAnimalsBasal Cell CarcinomaCarcinogenesisCell Line, TumorCell ProliferationDisease Models, AnimalDrug Resistance, NeoplasmHumansMiceMice, TransgenicPatched-1 ReceptorPhotochemotherapyPhotosensitizing AgentsProtoporphyrinsSkin NeoplasmsAminolevulinic Acidmethyl 5-aminolevulinatePatched-1 ReceptorPhotosensitizing Agentsprotoporphyrin IXProtoporphyrinsPtch1 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID30886381
PMCPMC6423284
OpenAlexW2922126409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.