Evidence map›Paper›PMID 30886334›Full record

ArticleMolecular psychiatry2020

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.

Golam M Khandaker, Verena Zuber, Jessica M B Rees, Livia Carvalho, Amy M Mason, Christopher N Foley, Apostolos Gkatzionis, Peter B Jones, Stephen Burgess

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 145 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 9 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 9 syntheses or guidelines pooled it, 271 citations in OpenAlex.

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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Golam M KhandakerDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Verena ZuberMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Jessica M B ReesCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Livia CarvalhoDepartment of Clinical Pharmacology, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-8862-0148
Amy M MasonCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8019-0777
Christopher N FoleyMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Apostolos GkatzionisMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Peter B JonesDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0387-880X
Stephen BurgessMRC Biostatistics Unit, University of Cambridge, Cambridge, UK. sb452@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0001-5365-8760
University of Cambridge · GBQueen Mary University of London · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_PC_17213Medical Research Council MC_UU_00002/7Wellcome Trust 201486/Z/16/ZWellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged participants of European ancestry from UK Biobank, a population-based cohort study, to assess whether comorbidity is primarily due to genetic or environmental factors, and to test whether cardiovascular risk factors and CHD are likely to be causally related to depression using Mendelian randomization. We showed family history of heart disease was associated with a 20% increase in depression risk (95% confidence interval [CI] 16-24%, p < 0.0001), but a genetic risk score that is strongly associated with CHD risk was not associated with depression. An increase of 1 standard deviation in the CHD genetic risk score was associated with 71% higher CHD risk, but 1% higher depression risk (95% CI 0-3%; p = 0.11). Mendelian randomization analyses suggested that triglycerides, interleukin-6 (IL-6), and C-reactive protein (CRP) are likely causal risk factors for depression. The odds ratio for depression per standard deviation increase in genetically-predicted triglycerides was 1.18 (95% CI 1.09-1.27; p = 2 × 10

Indexed as

Coronary DiseaseDepressionAdultAgedCohort StudiesC-Reactive ProteinFemaleHumansInterleukin-6MaleMendelian Randomization AnalysisMiddle AgedOdds RatioPolymorphism, Single NucleotideRisk FactorsTriglyceridesC-Reactive ProteinInterleukin-6Triglycerides

Identifiers

PMID30886334
PMCPMC7303009
OpenAlexW4231184754

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.