Evidence map›Paper›PMID 30886309›Full record

Observational studyScientific reports2019

Stability of radiomics features in apparent diffusion coefficient maps from a multi-centre test-retest trial.

Jurgen Peerlings, Henry C Woodruff, Jessica M Winfield, Abdalla Ibrahim, Bernard E Van Beers, Arend Heerschap, Alan Jackson, Joachim E Wildberger, Felix M Mottaghy, Nandita M DeSouza and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  6. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jurgen PeerlingsThe D-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Henry C WoodruffThe D-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands. h.woodruff@maastrichtuniversity.nl.ORCID 0000-0001-7911-5123
Jessica M WinfieldCancer Research UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK.
Abdalla IbrahimThe D-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Bernard E Van BeersLaboratory of Imaging Biomarkers, UMR 1149 Inserm - University Paris Diderot, Paris; Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France.
Arend HeerschapDepartment of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Alan JacksonWolfson Imaging Centre, Wolfson Molecular Imaging Centre, University of Manchester, 23 Palatine Rd, Withington, Greater Manchester, UK.ORCID 0000-0002-1623-0383
Joachim E WildbergerDepartment of Radiology and Nuclear Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Felix M MottaghyDepartment of Radiology and Nuclear Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Nandita M DeSouzaCancer Research UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK.
Philippe LambinThe D-Lab, Department of Precision Medicine, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Funding

Cancer Research UK 16464Cancer Research UK C1353/A12762Cancer Research UK C8742/A18097
6 · The paper itself

Abstract

Quantitative radiomics features, extracted from medical images, characterize tumour-phenotypes and have been shown to provide prognostic value in predicting clinical outcomes. Stability of radiomics features extracted from apparent diffusion coefficient (ADC)-maps is essential for reliable correlation with the underlying pathology and its clinical applications. Within a multicentre, multi-vendor trial we established a method to analyse radiomics features from ADC-maps of ovarian (n = 12), lung (n = 19), and colorectal liver metastasis (n = 30) cancer patients who underwent repeated (<7 days) diffusion-weighted imaging at 1.5 T and 3 T. From these ADC-maps, 1322 features describing tumour shape, texture and intensity were retrospectively extracted and stable features were selected using the concordance correlation coefficient (CCC > 0.85). Although some features were tissue- and/or respiratory motion-specific, 122 features were stable for all tumour-entities. A large proportion of features were stable across different vendors and field strengths. By extracting stable phenotypic features, fitting-dimensionality is reduced and reliable prognostic models can be created, paving the way for clinical implementation of ADC-based radiomics.

Indexed as

Colorectal NeoplasmsDiffusion Magnetic Resonance ImagingImage Interpretation, Computer-AssistedLiver NeoplasmsLung NeoplasmsOvarian NeoplasmsAdultAgedAged, 80 and overFemaleHumansLiverLungMiddle AgedOvaryProspective Studies

Identifiers

PMID30886309
PMCPMC6423042

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.