Evidence map›Paper›PMID 30886243›Full record

ArticleScientific reports2019

Proteomic profiling of whole-saliva reveals correlation between Burning Mouth Syndrome and the neurotrophin signaling pathway.

Guy Krief, Yaron Haviv, Omer Deutsch, Naama Keshet, Galit Almoznino, Batia Zacks, Aaron Palmon, Doron J Aframian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Chronic Pain in the Elderly: Mechanisms and Perspectives.Frontiers in human neuroscience · 2022
    Review
  9. Article
  10. Article
  11. Protein Signature in Saliva of Temporomandibular Disorders Myalgia.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Guy KriefInstitute of Dental Sciences, The Hebrew University, Jerusalem, Israel.
Yaron HavivSjogren's syndrome Center, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Faculty of Dental Medicine, The Hebrew University, Hadassah Medical Center, Jerusalem, Israel. yaronha@hadassah.org.il.
Omer DeutschInstitute of Dental Sciences, The Hebrew University, Jerusalem, Israel.
Naama KeshetSjogren's syndrome Center, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Faculty of Dental Medicine, The Hebrew University, Hadassah Medical Center, Jerusalem, Israel.
Galit AlmozninoSjogren's syndrome Center, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Faculty of Dental Medicine, The Hebrew University, Hadassah Medical Center, Jerusalem, Israel.
Batia ZacksSjogren's syndrome Center, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Faculty of Dental Medicine, The Hebrew University, Hadassah Medical Center, Jerusalem, Israel.
Aaron PalmonSjogren's syndrome Center, Department of Oral Medicine, Sedation and Maxillofacial Imaging, Faculty of Dental Medicine, The Hebrew University, Hadassah Medical Center, Jerusalem, Israel.
Doron J AframianInstitute of Dental Sciences, The Hebrew University, Jerusalem, Israel.
Hadassah Medical Center · ILHebrew University of Jerusalem · ILMinistry of Social Affairs and Social Services · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burning mouth syndrome (BMS) is characterized by a spontaneous and chronic sensation of burning in the oral mucosa, with no apparent signs. The underlying pathophysiological and neuropathic mechanisms remain unclear. Here, we attempt to elucidate some of these mechanisms using proteomic profiling and bioinformatic analyses of whole-saliva (WS) from BMS patients compared to WS from healthy individuals. Qualitative and quantitative proteomic profiling was performed using two dimensional gel electrophoresis (2-DE) and quantitative mass spectrometry (q-MS). In order to improve protein visibility, 21 high abundance proteins were depleted before proteomic profiling. Quantitative proteomic analysis revealed 100 BMS specific proteins and an additional 158 proteins up-regulated by more than threefold in those with BMS. Bioinformatic analyses of the altered protein expression profile of BMS group indicated high correlations to three cellular mechanisms including the neurotrophin signaling pathway. Based on this finding, we suggest that neurotrophin signaling pathway is involved in the pathophysiology of BMS by amplifying P75NTR activity, which in turn increases neural apoptosis thereby reducing sub-papillary nerve fiber density in the oral mucosa.

Indexed as

AgedAged, 80 and overBurning Mouth SyndromeFemaleHumansMaleMiddle AgedNerve Growth FactorsNerve Tissue ProteinsProteomeReceptors, Nerve Growth FactorSalivaSignal TransductionNerve Growth FactorsNerve Tissue ProteinsNGFR protein, humanProteomeReceptors, Nerve Growth Factor

Identifiers

PMID30886243
PMCPMC6423135
OpenAlexW2921414641

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.