ArticleScientific reports2019
Association between acute kidney injury and serum procalcitonin levels and their diagnostic usefulness in critically ill patients.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Serum activin A as a prognostic biomarker for community acquired pneumonia.World journal of clinical cases · 2024Trial
- Procalcitonin kinetics in critically ill patients: a retrospective analysis of the impact of renal dysfunction and renal replacement therapy.Journal of anesthesia, analgesia and critical care · 2026Article
- The Prognostic Value of Inflammatory Markers in Paediatric Acute Kidney Injury.Journal of clinical medicine · 2026Article
- Persistent Severe Acute Kidney Injury Among Critically Ill Patients: Outcomes and Predictive Markers-A Single-Center Retrospective Cohort Study.Critical care research and practice · 2026Article
- Highly elevated sepsis biomarkers in advanced cholangiocarcinoma without sepsis: A case report and literature review.Medicine · 2025Review
- ICU 'Magic Numbers': The Role of Biomarkers in Supporting Clinical Decision-Making.Diagnostics (Basel, Switzerland) · 2025Review
- A model for predicting AKI after cardiopulmonary bypass surgery in Chinese patients with normal preoperative renal function.BMC surgery · 2024Article
- The Utility of C-Reactive Protein, Procalcitonin, and Leukocyte Values in Predicting the Prognosis of Patients with Pneumosepsis and Septic Shock.Medicina (Kaunas, Lithuania) · 2024Observational
- Interleukin-6 and Procalcitonin as Potential Predictors of Acute Kidney Injury Occurrence in Patients with Sepsis.Reports of biochemistry & molecular biology · 2024Article
- Procalcitonin Guided Antibiotic Stewardship.Biomarker insights · 2024Review
- The roles of interleukin-17A in risk stratification and prognosis of patients with sepsis-associated acute kidney injury.Kidney research and clinical practice · 2023Article
- Unusual Extreme Leukocytosis in Metformin Overdose.Maedica · 2023Article
- The association between procalcitonin and acute kidney injury in patients stung by wasps.Frontiers in physiology · 2023Article
- Plasma presepsin level predicts acute kidney injury in patients with sepsis in the emergency department.Medicine · 2022Observational
- Clinico-bacterial and prognostic factors in patients with suspected blood stream infection and elevated serum procalcitonin levels.Nagoya journal of medical science · 2022Article
- Postoperative serum myoglobin as a predictor of early allograft dysfunction after liver transplantation.Frontiers in surgery · 2022Article
- Estradiol Ameliorates Acute Kidney Ischemia-Reperfusion Injury by Inhibiting the TGF-βRI-SMAD Pathway.Frontiers in immunology · 2022Article
- Procalcitonin and High APACHE (Acute Physiological and Chronic Health Evaluation) Level Are Associated with the Course of Acute Kidney Injury in Patients with SARS-CoV-2.International journal of clinical practice · 2022Article
- Analysis of the diagnostic capabilities of urinary neutrophil gelatinase-associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission.Journal of clinical laboratory analysis · 2021Article
- Predictive Ability of Procalcitonin for Acute Kidney Injury: A Narrative Review Focusing on the Interference of Infection.International journal of molecular sciences · 2021Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Procalcitonin (PCT) is a useful marker for the diagnosis of systemic inflammatory response syndrome. In addition, PCT is affected by renal function. However, few studies have investigated the relationship between PCT and the development of acute kidney injury (AKI). Hence, we investigated whether serum PCT levels at the time of admission were associated with the development of AKI and clinical outcomes. A total of 790 patients in whom PCT was measured on admission to the intensive care unit (ICU) were analyzed retrospectively. We attempted to investigate whether serum PCT levels measured at the time of admission could be used as a risk factor for the development of AKI in septic and nonseptic patients or as a risk factor for all-cause mortality, and diagnostic usefulness of PCT was further assessed. Serum PCT levels were significantly higher in patients with AKI than in those without AKI (P < 0.001). After multivariable adjustment for clinical factors, laboratory findings, and comorbidities, PCT as a continuous variable showed a significant association with AKI (OR 1.006, 95% CI [1.000-1.011]; P = 0.035). However, PCT was not effective in predicting mortality. The cut-off value of PCT for the prediction of AKI incidence was calculated to be 0.315 ng/ml, with sensitivity and specificity of 60.9% and 56.9%, respectively. The odds ratios (ORs) from an equation adjusted for optimum thresholds of PCT levels for developing AKI with and without sepsis were 2.422 (1.222-4.802, P = 0.011) and 1.798 (1.101-2.937, P = 0.019), respectively. However, there were no absolute differences between the pre- and posttest probabilities after including the PCT value for AKI development. This study suggests that the PCT value was higher in AKI patients than in non-AKI patients, but PCT measurement at the time of admission did not improve the prediction model for AKI.
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