ArticleCancer research2019
Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
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21citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma.Acta neuropathologica communications · 2026Article
- A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies.Cancer cell · 2026Article
- Choroid plexus carcinoma: state of the field and emerging directions.Oncogenesis · 2026Review
- MYC as a Target for Cancer Treatment: from Undruggable to Druggable?Targeted oncology · 2025Review
- A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc-haploinsufficiency in the absence of p53.bioRxiv : the preprint server for biology · 2025Article
- Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus.Neuro-oncology · 2025Article
- Choroid Plexus Pathophysiology.Annual review of pathology · 2025Review
- Article
- Single-nucleus RNA-seq dissection of choroid plexus tumor cell heterogeneity.The EMBO journal · 2024Article
- Degradation of MYC by the mutant p53 reactivator drug, COTI-2 in breast cancer cells.Investigational new drugs · 2023Article
- Cancer Stem Cells in Tumours of the Central Nervous System in Children: A Comprehensive Review.Cancers · 2023Review
- Preclinical validation of a novel therapeutic strategy for choroid plexus carcinoma.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Proof-of-Concept for Liquid Biopsy Disease Monitoring ofCancers · 2023Article
- Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors.Journal for immunotherapy of cancer · 2022Article
- Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.Cell death and differentiation · 2022Article
- Experimental approaches for manipulating choroid plexus epithelial cells.Fluids and barriers of the CNS · 2022Review
- Choroid plexus carcinoma in two siblings, with a novel genetic mutation in TP53 - A case report and review of literature.Surgical neurology international · 2022Article
- Notch1 switches progenitor competence in inducing medulloblastoma.Science advances · 2021Article
- Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors.Journal of neuro-oncology · 2021Article
- Emergence and Developmental Roles of the Cerebrospinal Fluid System.Developmental cell · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 10 institutions in 3 countries.
Jun WangTumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.ORCID 0000-0001-8751-9216
Diana M MerinoDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6173-6957
Nicholas LightProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Brian L MurphyDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Yong-Dong WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID 0000-0001-8751-9216
Xiaohui GuoBioinformatics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Andrew P HodgesBioinformatics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.ORCID 0000-0002-5100-8673
Lianne Q ChauTumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Kun-Wei LiuTumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
Girish DhallDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles.
Shahab AsgharzadehDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles.ORCID 0000-0002-0510-3848
Erin N KiehnaDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles.
Ryan J ShireyDepartment of Chemistry, The Scripps Research Institute, La Jolla, California.ORCID 0000-0002-6715-5328
Kim D JandaDepartment of Chemistry, The Scripps Research Institute, La Jolla, California.
Michael D TaylorDivision of Neurosurgery and Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
David MalkinProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
David W EllisonDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Scott R VandenBergUCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Charles G EberhartDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rosalie C SearsMolecular and Medical Genetics Department, Oregon Health and Sciences University, Portland, Oregon.
Martine F RousselDepartment of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Richard J GilbertsonCancer Research UK Cambridge Centre, CRUK Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-7539-9472
Robert J Wechsler-ReyaTumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. rwreya@sbpdiscovery.org.
Discovery Institute · USSt. Jude Children's Research Hospital · USCenter for Cancer and Blood Disorders · USUniversity of Toronto · CAScripps Research Institute · USCancer Research UK Cambridge Center · GBHospital for Sick Children · CAJohns Hopkins University · USOregon Health & Science University · USUCSF Helen Diller Family Comprehensive Cancer Center · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MTumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4MThe DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0MMouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4MHydroxylation regulation of c-MycR01CA186241 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mu-Shui Dai, ROSALIE C SEARS · 2015 to 2026
$4.2MStem Cells, Progenitors, and the Origin of MedulloblastomaR01CA122759 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI WECHSLER-REYA, ROBERT J. · 2009 to 2013
$1.8MCancer Research UK 22492Cancer Research UK 26398NCI NIH HHS P01 CA096832NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA030199NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA122759NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA186241
Abstract
Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. Improved outcomes for patients with CPC depend on a deeper understanding of the mechanisms underlying the disease. Here we developed transgenic models of CPCs by activating the
Indexed as
AnimalsAntineoplastic AgentsCarcinomaChoroid Plexus NeoplasmsHigh-Throughput Screening AssaysMiceMice, KnockoutNeural Stem CellsProto-Oncogene Proteins c-mycSmall Molecule LibrariesTumor Cells, CulturedTumor Suppressor Protein p53Antineoplastic AgentsMyc protein, mouseProto-Oncogene Proteins c-mycSmall Molecule LibrariesTrp53 protein, mouseTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.