Evidence map›Paper›PMID 30885959›Full record

ArticleEMBO molecular medicine2019

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7.

Karthik Mohanraj, Michal Wasilewski, Cristiane Benincá, Dominik Cysewski, Jaroslaw Poznanski, Paulina Sakowska, Zaneta Bugajska, Markus Deckers, Sven Dennerlein, Erika Fernandez-Vizarra and 4 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 77 citations in OpenAlex.

  1. Quality control of protein import into mammalian mitochondria.Protein science : a publication of the Protein Society · 2026
    Review
  2. Article
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  6. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Review
  8. Common methods in mitochondrial research (Review).International journal of molecular medicine · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. A second chance for protein targeting/folding: Ubiquitination and deubiquitination of nascent proteins.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. CHCHD4 (MIA40) and the mitochondrial disulfide relay system.Biochemical Society transactions · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Karthik MohanrajLaboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Michal WasilewskiLaboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland m.wasilewski@cent.uw.edu.pl a.chacinska@cent.uw.edu.pl.ORCID 0000-0002-4890-5103
Cristiane BenincáMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
Dominik CysewskiMass Spectrometry Lab, Department of Biophysics, Institute of Biochemistry and Biophysics, Warsaw, Poland.
Jaroslaw PoznanskiDepartment of Biophysics, Institute of Biochemistry and Biophysics, Warsaw, Poland.
Paulina SakowskaLaboratory of Mitochondrial Biogenesis, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Zaneta BugajskaLaboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Markus DeckersDepartment of Cellular Biochemistry, University of Göttingen, Göttingen, Germany.
Sven DennerleinDepartment of Cellular Biochemistry, University of Göttingen, Göttingen, Germany.
Erika Fernandez-VizarraMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2469-142X
Peter RehlingDepartment of Cellular Biochemistry, University of Göttingen, Göttingen, Germany.
Michal DadlezMass Spectrometry Lab, Department of Biophysics, Institute of Biochemistry and Biophysics, Warsaw, Poland.
Massimo ZevianiMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-9067-5508
Agnieszka ChacinskaLaboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland m.wasilewski@cent.uw.edu.pl a.chacinska@cent.uw.edu.pl.ORCID 0000-0002-2832-2568
International Institute of Molecular and Cell Biology · PLInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLUniversity of Cambridge · GBUniversity of Göttingen · DEMax Planck Institute for Biophysical Chemistry · DEUniversity of Warsaw · PL

Funding

Medical Research Council MC_UP_1002/1Medical Research Council MC_UU_00015/5Medical Research Council MC_UU_00015/7Medical Research Council MC_UU_00015/8
6 · The paper itself

Abstract

Nuclear and mitochondrial genome mutations lead to various mitochondrial diseases, many of which affect the mitochondrial respiratory chain. The proteome of the intermembrane space (IMS) of mitochondria consists of several important assembly factors that participate in the biogenesis of mitochondrial respiratory chain complexes. The present study comprehensively analyzed a recently identified IMS protein cytochrome

Indexed as

CytosolDisulfidesElectron TransportFibroblastsHEK293 CellsHeLa CellsHumansMitochondriaMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsMutant ProteinsMutationOxidation-ReductionProteasome Endopeptidase ComplexCHCHD4 protein, humanCOA7 protein, humanDisulfidesMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsMutant ProteinsProteasome Endopeptidase ComplexProteasome InhibitorsUbiquitinCOA7/RESA1mitochondrial diseaseproteasomeprotein degradationprotein import

Identifiers

PMID30885959
PMCPMC6505684
OpenAlexW2921496226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.