Evidence map›Paper›PMID 30885940›Full record

ArticleThe Journal of biological chemistry2019

XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection.

Kevin J Barnum, Y Tram Nguyen, Matthew J O'Connell

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Association ofWorld journal of gastroenterology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Kevin J BarnumFrom the Department of Oncological Sciences and.
Y Tram NguyenFrom the Department of Oncological Sciences and.
Matthew J O'ConnellFrom the Department of Oncological Sciences and matthew.oconnell@mssm.edu.ORCID 0000-0002-0061-2504
Angiologica (Italy) · ITIcahn School of Medicine at Mount Sinai · US

Funding

TRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6M
Processing of lesions into DNA repair and checkpoint pathwaysR01GM124079 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI O'CONNELL, MATTHEW J · 2017 to 2023
$2.1M
New determinants of the DNA damage response in the fission yeast S. pombeR01GM087326 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI O'CONNELL, MATTHEW J · 2010 to 2013
$1.3M
NCI NIH HHS T32 CA078207NIGMS NIH HHS R01 GM087326NIGMS NIH HHS R01 GM124079
6 · The paper itself

Abstract

dsDNA breaks (DSBs) are resected in a 5'→3' direction, generating single-stranded DNA (ssDNA). This promotes DNA repair by homologous recombination and also assembly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1. In fission yeast (

Indexed as

DNA Breaks, Double-StrandedDeoxyribonucleasesDNA, FungalDNA, RibosomalEndodeoxyribonucleasesHumansRNA, FungalRNA, Ribosomal, 28SSchizosaccharomycesSchizosaccharomyces pombe ProteinsAst1 protein, S pombeDeoxyribonucleasesDNA, FungalDNA, RibosomalEndodeoxyribonucleasesRad2 protein, S pombeRNA, FungalRNA, Ribosomal, 28SSchizosaccharomyces pombe Proteinscell cycleCheckpointchromosomesDNA damage responseDNA Damage ResponseDNA recombinationDNA repairDNA RepairSchizosaccharomyces pombeXPG-Related Nuclease

Identifiers

PMID30885940
PMCPMC6514642
OpenAlexW2920868413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.