Evidence map›Paper›PMID 30885843›Full record

ArticleBrain, behavior, and immunity2019

Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between-, within-person associations in a longitudinal study of older adults.

Rebecca G Reed, Steven R Presnell, Ahmad Al-Attar, Charles T Lutz, Suzanne C Segerstrom

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Resources and lymphocyte terminal maturity among older adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebecca G ReedDepartment of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United States; Department of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States. Electronic address: rebecca.reed@uky.edu.
Steven R PresnellDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States.
Ahmad Al-AttarDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States.
Charles T LutzDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United States; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, United States.
Suzanne C SegerstromDepartment of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United States.
University of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
University of Kentucky Alzheimer's Disease Core Center - Biomarker CoreP30AG028383 · NIA · UNIVERSITY OF KENTUCKY · PI VAN ELDIK, LINDA J · 2006 to 2020
$23.3M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Self-Regulation, Immunological Aging, and Health in Older AdultsR01AG026307 · NIA · UNIVERSITY OF KENTUCKY · PI GOLD, BRIAN TIMOTHY, SEGERSTROM, SUZANNE C. · 2006 to 2022
$7.5M
Stress and Immunosenescence: Protective Effects of Emotion RegulationR00AG056635 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REED, REBECCA G · 2019 to 2021
$742k
Self-Regulation and Aging: Substrates and Health ConsequencesK02AG033629 · NIA · UNIVERSITY OF KENTUCKY · PI SEGERSTROM, SUZANNE C. · 2012 to 2016
$703k
Stress and Immunosenescence: Protective Effects of Emotion RegulationK99AG056635 · NIA · UNIVERSITY OF KENTUCKY · PI REED, REBECCA G · 2017 to 2018
$219k
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIA NIH HHS K02 AG033629NIA NIH HHS K99 AG056635NIA NIH HHS P30 AG028383NIA NIH HHS R00 AG056635NIA NIH HHS R01 AG026307
6 · The paper itself

Abstract

Cytomegalovirus (CMV) and psychological stress are implicated as drivers of immunological aging. It is unknown, however, whether associations among CMV titers, stress, and immune aging are more stable or dynamic over time. The present investigation tested the between-person (stable differences) and within-person (dynamic fluctuations) associations of CMV titers and perceived stress on late-differentiated T and natural killer (NK) peripheral blood cells in a longitudinal study of older adults aged 64-92 years (N = 149). Participants reported stress levels and provided blood biannually for 2.5 years (up to 5 waves per person) to assess CMV IgG titers and composites of late-differentiated CD8 T cells (CD28- and CD57 + subsets) and CD56

Indexed as

AgedAged, 80 and overAgingCD8-Positive T-LymphocytesCytomegalovirusFemaleHumansKiller Cells, NaturalLongitudinal StudiesMaleMiddle AgedStress, PsychologicalAgingCytomegalovirusImmunosenescenceLongitudinalPsychological stress

Identifiers

PMID30885843
PMCPMC6660394
OpenAlexW2921381419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.