ReviewNeuroscience and biobehavioral reviews2019
Changing conceptualizations of regression: What prospective studies reveal about the onset of autism spectrum disorder.
Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Diagnostic Yield of Investigating Developmental Regression in Children: A Systematic Review and Meta-Analysis.Journal of autism and developmental disorders · 2026Pooled it
- Pooled it
- The Emergence of Autism Symptoms Prior to 18 Months of Age: A Systematic Literature Review.Journal of autism and developmental disorders · 2021Pooled it
- Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial.Jornal de pediatriaTrial
- Catatonic Features That May Be Mistaken for Worsening Autism Show Treatment-Associated Improvement: Implications for Later Regression.medRxiv : the preprint server for health sciences · 2026Article
- Developmental Trajectories of Autistic Traits in Infants With Autism and/or ADHD Family History: Predictors and Mid-Childhood Outcomes.Journal of autism and developmental disorders · 2026Article
- Patterns of Early Development in Children with ADHD.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026Article
- Social regression stems from a latent phase of GABAergic dysfunction and sensory breakdown in a model of synaptopathy.Molecular psychiatry · 2026Article
- Self-reported vaccine hesitancy and refusal among parents of children with autism spectrum disorder and other developmental delays: a cross-sectional study.European journal of pediatrics · 2026Article
- Association between craniosynostosis and neurodevelopmental disorders: a nationwide claims database.BMC pediatrics · 2026Article
- Application of Psychometric Methods in Dimensional Analysis and Integration of Assessment Tools in Early Diagnosis for Autism Spectrum Disorder.Journal of clinical psychology · 2026Article
- Decoding cortical folding with deep learning: toward neurodevelopmental biomarkers of psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Cerebral folate deficiency, developmental difficulties in autism spectrum disorder and the role of leucovorin: a narrative review of mechanisms and clinical evidence.Drugs in context · 2026Review
- Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.Molecular psychiatry · 2025Review
- Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population-Based Birth Cohort Study.Autism research : official journal of the International Society for Autism Research · 2025Article
- Towards an agreed approach to investigate children with developmental regression.BMJ paediatrics open · 2025Article
- Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies.Brain sciences · 2025Review
- Retrospective Reports of Skill Attainment and Loss in Phelan-McDermid Syndrome.American journal on intellectual and developmental disabilities · 2025Article
- Unraveling genetic risk contributions to nonverbal status in autism spectrum disorder probands.Behavioral and brain functions : BBF · 2025Article
- Comparative Analysis of Phenotypic and Genotypic Differences Between Individuals Affected by Regressive and Non-Regressive Autism: A Cross-Sectional Study.Autism research : official journal of the International Society for Autism Research · 2025Article
18 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Until the last decade, studies of the timing of early symptom emergence in autism spectrum disorder (ASD) relied upon retrospective methods. Recent investigations, however, are raising significant questions about the accuracy and validity of such data. Questions about when and how behavioral signs of autism emerge may be better answered through prospective studies, in which infants are enrolled near birth and followed longitudinally until the age at which ASD can be confidently diagnosed or ruled out. This review summarizes the results of recent studies that utilized prospective methods to study infants at high risk of developing ASD due to family history. Collectively, prospective studies demonstrate that the onset of ASD involves declines in the rates of key social and communication behaviors during the first years of life for most children. This corpus of literature suggests that regressive onset patterns occur much more frequently than previously recognized and may be the rule rather than the exception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.