ArticleProceedings of the National Academy of Sciences of the United States of America1986
Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 102 citations in OpenAlex.
- A long non-coding RNA-messenger RNA regulatory network associated with residual feed intake in the olfactory tissue of meat ducks.Poultry science · 2026Article
- Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research.Current neuropharmacology · 2019Article
- Identification of a Novel Gnao-Mediated Alternate Olfactory Signaling Pathway in Murine OSNs.Frontiers in cellular neuroscience · 2016Article
- Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation.BMC cardiovascular disorders · 2013Article
- Expression profile of G-protein βγ subunit gene transcripts in the mouse olfactory sensory epithelia.Frontiers in cellular neuroscience · 2013Article
- Olfactory receptors: G protein-coupled receptors and beyond.Journal of neurochemistry · 2009Review
- Mammalian olfactory receptors.Frontiers in cellular neuroscience · 2009Article
- Solution structure of a chemosensory protein from the moth Mamestra brassicae.The Biochemical journal · 2003Article
- Cyclic AMP diffusion coefficient in frog olfactory cilia.Biophysical journal · 1999Article
- The variable and conserved interfaces of modeled olfactory receptor proteins.Protein science : a publication of the Protein Society · 1999Article
- Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans.Genetics · 1994Article
- Characteristics of specific 125I-omega-conotoxin GVIA binding in rat whole brain.Neurochemical research · 1993Article
- Cytochemical localization of cyclic 3',5'-nucleotide phosphodiesterase activity in the rat olfactory mucosa.The Histochemical journal · 1993Article
- Four cases of direct ion channel gating by cyclic nucleotides.Journal of bioenergetics and biomembranes · 1991Review
- Somatic sodium channels of frog olfactory receptor neurones are inactivated at rest.Pflugers Archiv : European journal of physiology · 1991Article
- The response induced by intracellular cyclic AMP in isolated olfactory receptor cells of the newt.The Journal of physiology · 1990Article
- The detergent Solulan C-24 reveals properties of the olfactory adenylate cyclase system.The Biochemical journal · 1989Article
- The influence of temperature and membrane-fluidity changes on the olfactory adenylate cyclase of the rat.The Biochemical journal · 1987Article
- G protein and diacylglycerol regulate metamorphosis of planktonic molluscan larvae.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sense of smell involves the stimulation of sensory neurons by odorants to produce depolarization and action potentials. We show that olfactory responses may be mediated by a GTP-binding protein (G protein), a homolog of the visual, hormonal, and brain signal transducing polypeptides. The olfactory G protein is identified in isolated dendritic membranes (olfactory cilia preparations) of chemosensory neurons from three vertebrate species and is shown to mediate the stimulation by odorants of the highly active adenylate cyclase in these membranes. The G protein of olfactory neurons is most similar to Gs, the hormonal stimulatory GTP-binding protein. Its alpha subunit has a molecular weight of about 42,000, and it undergoes ADP-ribosylation catalyzed by cholera toxin that leads to adenylate cyclase activation. The slight difference in molecular weights of the frog olfactory and the liver Gs alpha subunits and the higher sensitivity of olfactory adenylate cyclase to nonhydrolyzable GTP analogs are consistent with the possible existence of different Gs variants. Signal amplification due to the olfactory G protein may be responsible for the unusual acuity of the sense of smell.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.