ArticleProceedings of the National Academy of Sciences of the United States of America1986
Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.Molecular and cellular biology · 2001Article
- A flower-specific Myb protein activates transcription of phenylpropanoid biosynthetic genes.The EMBO journal · 1994Article
- Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.Molecular and cellular biology · 1993Article
- New sites of proviral integration associated with murine promonocytic leukemias and evidence for alternate modes of c-myb activation.Journal of virology · 1992Article
- Expression of the CD4 gene requires a Myb transcription factor.Molecular and cellular biology · 1992Article
- Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells.Molecular and cellular biology · 1992Article
- Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.Journal of virology · 1992Article
- Protein truncation is required for the activation of the c-myb proto-oncogene.Molecular and cellular biology · 1991Article
- Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): clonal integrations involve c-myb in some but not all leukemias.Journal of virology · 1991Article
- cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.Molecular and cellular biology · 1990Article
- Functional analysis of c-Myb protein in T-lymphocytic cell lines shows that it trans-activates the c-myc promoter.Molecular and cellular biology · 1990Article
- Enhanced translation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells.Molecular and cellular biology · 1990Article
- Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.The EMBO journal · 1990Article
- Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Hematopoietic lineage-specific heterogeneity in the 5'-terminal region of the chicken proto-myb transcript.Molecular and cellular biology · 1989Article
- Transcription of the chicken myb proto-oncogene starts within a CpG island.Nucleic acids research · 1989Article
- Murine myeloid cell lines derived by in vitro infection with recombinant c-myb retroviruses express myb from rearranged vector proviruses.The EMBO journal · 1989Article
- Nucleotide sequence of chicken myb proto-oncogene promoter region: detection of an evolutionarily conserved element.Nucleic acids research · 1988Article
- DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation.Journal of virology · 1988Article
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3 authors.
Funding
Abstract
Antibodies directed against a bacterial fusion protein that contains the domain encoded by the highly evolutionarily conserved 5' one-third of the v-myb oncogene of avian myeloblastosis virus (AMV) detect the protein products of various members of the myb gene family. Immunoprecipitation or immunoblot analyses with these antibodies yielded the following information. First, the products of the v-myb oncogenes of AMV (p48v-myb) and of E26 virus (p135gag-myb-ets) contain this highly conserved amino acid sequence, as previously hypothesized. Second, p75c-myb, the product of the chicken c-myb protooncogene, also contains this protein domain. Third, these antibodies have identified the products of the human, murine, and Drosophila c-myb genes, which were all found to be nuclear proteins of Mr 75,000-80,000. The human c-myb protein product is present in immature cells of the erythroid, myeloid, and lymphoid lineages.
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