ArticleJournal of pediatric surgery2019
Association between image-defined risk factors and neuroblastoma outcomes.
Article in Journal of pediatric surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Image defined risk factor(s) and outcomes for abdominal neuroblastoma: a surgical perspective from a Thailand National Cancer Centre.Pediatric surgery international · 2026Article
- Association of image-defined risk factors with clinical features in thoracic neuroblastoma and the development of a prognostic prediction model.Frontiers in pediatrics · 2026Article
- Vascular encasement image defined risk factors independently predict surgical complications in neuroblastoma.ANZ journal of surgery · 2025Article
- Evaluation of Image-Defined Risk Factor (IDRF) Assessment in Patients With Intermediate-risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531.Journal of pediatric surgery · 2025Article
- Cadaveric analysis of surgical techniques and working space for retroperitoneal tumors as model for improving resection of neuroblastoma.BMC surgery · 2024Article
- Image-defined risk factors associated with MYCN oncogene amplification in neuroblastoma and their association with overall survival.Abdominal radiology (New York) · 2024Article
- Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients.World journal of pediatrics : WJP · 2024Article
- Characteristics of image defined risk factors on outcomes for primary resection of neuroblastoma.Surgery in practice and science · 2023Article
- Beyond image defined risk factors (IDRFs): a delphi survey highlighting definition of the surgical complexity index (SCI) in neuroblastoma.Pediatric surgery international · 2023Article
- Association of image-defined risk factors with clinical features, tumor biology, and outcomes in neuroblastoma: a single-center retrospective study.European journal of pediatrics · 2023Article
- High-Risk Neuroblastoma: A Surgical Perspective.Children (Basel, Switzerland) · 2023Review
- Correlation between image-defined risk factors and surgical complications in patients with neuroblastoma: a retrospective study.Pediatric surgery international · 2023Article
- Changes in image-defined risk factors with neoadjuvant chemotherapy in pediatric abdominal neuroblastoma.Abdominal radiology (New York) · 2022Article
- Surgical approach to pediatric mediastinal masses based on imaging characteristics.Pediatric surgery international · 2022Article
- Prognostic impact of tumor size on patients with neuroblastoma in a SEER-based study.Cancer medicine · 2022Article
- Prediction of MYCN Amplification, 1p and 11q Aberrations in Pediatric NeuroblastomaFrontiers in medicine · 2022Article
- Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma.Cancer medicine · 2021Article
- Effects of preoperative chemotherapy on neuroblastoma withWorld journal of pediatric surgery · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe current neuroblastoma (NBL) staging system employs image-defined risk factors (IDRFs) to assess numerous anatomic features, but the impact of IDRFs on surgical and oncologic outcomes is unclear.
methodsThe Vanderbilt Cancer Registry identified children treated for NBL from 2002 to 2017. Tumor volume (TV) and IDRFs were measured radiographically at diagnosis and before resection. Perioperative and oncologic outcomes were evaluated.
resultsAt diagnosis of 106 NBL, 61% were IDRF positive. MYCN-amplified and undifferentiated NBL had more IDRFs than nonamplified and more differentiated tumors (p = 0.001 and p = 0.01). Of 86 NBLs resected, 43% were IDRF positive, which associated with higher stage, risk, and TV (each p < 0.001). The presence of IDRF at resection was also associated with increased blood loss (p < 0.001), longer operating times (p < 0.001), greater incidence of intraoperative complications (p = 0.03), more frequent ICU admissions postoperatively (p < 0.001), and longer hospital stays (p < 0.001). IDRF negative and positive tumors did not have significantly different rates of gross total resection (p = 0.2). Five-year relapse-free and overall survival was similar for IDRF negative and positive NBL (p = 0.9 and p = 0.8).
conclusionsIDRFs at diagnosis were associated with larger, less differentiated, advanced stage, and higher risk NBL and at resection with increased operative difficulty and perioperative morbidity. However, the frequency of gross total resection and patient survival after resection were not associated with the presence of IDRFs. TYPE OF STUDY: Retrospective cohort study. LEVEL OF EVIDENCE: Level III.
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