Evidence map›Paper›PMID 30885307›Full record

ArticleVeterinary immunology and immunopathology2019

Breed-specific variations in the coding region of toll-like receptor 4 in the domestic cat.

J Whitney, B Haase, J Beatty, V R Barrs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary immunology and immunopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J WhitneySydney School of Veterinary Science, Faculty of Science, University of Sydney, NSW 2006, Australia. Electronic address: joannaw@uni.sydney.edu.au.
B HaaseSydney School of Veterinary Science, Faculty of Science, University of Sydney, NSW 2006, Australia. Electronic address: bianca.waud@sydney.edu.au.
J BeattySydney School of Veterinary Science, Faculty of Science, University of Sydney, NSW 2006, Australia; Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, NSW 2006, Australia. Electronic address: julia.beatty@sydney.edu.au.
V R BarrsSydney School of Veterinary Science, Faculty of Science, University of Sydney, NSW 2006, Australia; Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, NSW 2006, Australia. Electronic address: vanessa.barrs@sydney.edu.au.
The University of Sydney · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific point mutations in the human toll-like receptor 4 (TLR4) confer altered risk for diverse diseases including sepsis, aspergillosis and inflammatory bowel disease. Some of these TLR4 polymorphisms are racially specific. We hypothesised that feline TLR4 polymorphisms might underlie an observed increased risk to infectious and inflammatory diseases in some cat breeds. The aim of this study was to identify breed-specific variations in the coding region of feline TLR4 and to model the effect of mutations on protein structure and function in silico. The entire coding region of TLR4 was sequenced in 8 groups (7 pure-bred, 1 crossbred) of domestic cats (Felis catus) comprising 158 individuals. Twenty-two single nucleotide polymorphisms (SNPs) were identified in TLR4, with 16 located in the coding region (11 non-synonymous) and four in the 3'UTR. Comparison of breed specific allelic frequencies indicated that Burmese and British shorthairs most commonly differed from other breeds. In silico analyses to predict the impact of the 11 non-synonymous variants indicated a deleterious effect on protein structure for one SNP (c.869 G > A), which was not associated with a specific breed. Overall, findings from this study do not support a role of TLR4 dysfunction in breed-predispositions to infectious diseases in domestic cats in Australia.

Indexed as

AnimalsCat DiseasesCatsGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansPoint MutationPolymorphism, GeneticProtein ConformationSpecies SpecificityToll-Like Receptor 4Toll-Like Receptor 4BreedFelinePolymorphismToll-like receptor 4

Identifiers

PMID30885307
PMCPMC7126157
OpenAlexW2916143797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.