Evidence map›Paper›PMID 30885256›Full record

ArticleTrials2019

Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): study protocol for a randomized controlled trial.

Silje Haukenes Stavestrand, Kristine Sirevåg, Inger Hilde Nordhus, Trond Sjøbø, Trygve Bruun Endal, Hans M Nordahl, Karsten Specht, Åsa Hammar, Anne Halmøy, Egil W Martinsen and 5 more

Erratum issued Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02690441 (Physical Exercise Augmented Cognitive Behaviour Therapy for Older Adults With Generalised Anxiety Disorder), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02690441 naactive not recruitingnot on this map

Physical Exercise Augmented Cognitive Behaviour Therapy for Older Adults With Generalised Anxiety Disorder

TypeinterventionalSponsorSolli Distriktspsykiatriske SenterRan2016 to 2026Enrolled53ConditionsGeneralized Anxiety DisorderArmsCognitive Behavioural Therapy, Physical Exercise, Placebo control
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 3 countries.

Silje Haukenes StavestrandFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway. silje.h.stavestrand@uib.no.ORCID http://orcid.org/0000-0002-7095-8754
Kristine SirevågFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Inger Hilde NordhusFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Trond SjøbøSolli DPS, Osvegen 15, NO-5228, Nesttun, Norway.
Trygve Bruun EndalSolli DPS, Osvegen 15, NO-5228, Nesttun, Norway.
Hans M NordahlDepartment of Mental Health, Norwegian University of Science and Technology, Box 8905, NO-7491, Trondheim, Norway.
Karsten SpechtFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Åsa HammarFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Anne HalmøyFaculty of Medicine, K.G. Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Egil W MartinsenFaculty of Medicine, University of Oslo, Box 1078, Blindern, NO-0316, Oslo, Norway.
Eva AnderssonThe Swedish School of Sport and Health Sciences, GIH, Box 5626, SE-114 86, Stockholm, Sweden.
Helene HjelmervikFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
Jan MohlmanDepartment of Psychology, William Paterson University, 300 Pompton Road, Wayne, NJ, 07470, USA.
Julian F ThayerDepartment of Psychology, Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA.
Anders HovlandFaculty of Psychology, University of Bergen, Box 7800, NO-5020, Bergen, Norway.
University of Bergen · NOCFD Marine (Norway) · NOHaukeland University Hospital · NONorwegian University of Science and Technology · NOOslo University Hospital · NOSwedish School of Sport and Health Sciences · SEThe Ohio State University · USUniversity of Oslo · NOWilliam Paterson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGeneralised anxiety disorder (GAD) is a frequent and severe anxiety disorder among older adults. GAD increases the risk of developing other disorders such as depression and coronary heart disease. Older adults with GAD exhibit a poorer response to cognitive behaviour therapy (CBT) compared to younger patients with GAD. The normal age-related cognitive decline can be a contributor to reduced treatment efficacy. One strategy for improving treatment efficacy is to combine CBT with adjunctive interventions targeted at improving cognitive functions. Physical exercise is a viable intervention in this regard. Increased levels of brain-derived neurotrophic factor may mediate improvement in cognitive function. The present study aims to investigate the proposed effects and mechanisms related to concomitant physical exercise.

methodsThe sample comprises 70 participants aged 60-75 years, who have GAD. Exclusion criteria comprise substance abuse and unstable medication; inability to participate in physical exercise; and conditions which precludes GAD as primary diagnosis. The interventions are individual treatment in the outpatient clinic at the local psychiatric hospital, with two experimental arms: (1) CBT + physical exercise and (2) CBT + telephone calls. The primary outcome measure is symptom reduction on the Penn State Worry Questionnaire. Other measures include questionnaires, clinical interviews, physiological, biological and neuropsychological tests. A subset of 40 participants will undergo magnetic resonance imaging (MRI). After inclusion, participants undergo baseline testing, and are subsequently randomized to a treatment condition. Participants attend five sessions of the add-on treatment in the pre-treatment phase, and move on to interim testing. After interim testing, participants attend 10 sessions of CBT in parallel with continued add-on treatment. Participants are tested post-intervention within 2 weeks of completing treatment, with follow-up testing 6 and 12 months later. DISCUSSION: This study aims to develop better treatment for GAD in older adults. Enhancing treatment response will be valuable from both individual and societal perspectives, especially taking the aging of the general population into account.

trial registrationClinicalTrials.gov, NCT02690441 . Registered on 24 February 2016.

Indexed as

Cognitive Behavioral TherapyExerciseRandomized Controlled Trials as TopicAgedAnxiety DisordersHumansMagnetic Resonance ImagingMiddle AgedSingle-Blind MethodBrain-derived neurotrophic factorCBTCognitive behavioural therapyExecutive functionGADGeneralised anxiety disorderOlder adultsPhysical exerciseRCT

Identifiers

PMID30885256
PMCPMC6423789
OpenAlexW2936137971

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.