Evidence map›Paper›PMID 30885243›Full record

ReviewMicrobial cell factories2019

Challenges and tackles in metabolic engineering for microbial production of carotenoids.

Chonglong Wang, Shuli Zhao, Xixi Shao, Ji-Bin Park, Seong-Hee Jeong, Hyo-Jin Park, Won-Ju Kwak, Gongyuan Wei, Seon-Won Kim

Abstract readReview
In one paragraph

Review in Microbial cell factories, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. UsingACS ES&T engineering · 2026
    Article
  3. Article
  4. Review
  5. Deinoxanthin Recovers HAntioxidants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. An engineeredSynthetic and systems biotechnology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chonglong WangSchool of Biology and Basic Medical Sciences, Soochow University, 199 Renai Road, Suzhou, 215123, People's Republic of China. clwang@suda.edu.cn.
Shuli ZhaoSchool of Biology and Basic Medical Sciences, Soochow University, 199 Renai Road, Suzhou, 215123, People's Republic of China.
Xixi ShaoSchool of Biology and Basic Medical Sciences, Soochow University, 199 Renai Road, Suzhou, 215123, People's Republic of China.
Ji-Bin ParkDivision of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Republic of Korea.
Seong-Hee JeongDivision of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Republic of Korea.
Hyo-Jin ParkDivision of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Republic of Korea.
Won-Ju KwakDivision of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Republic of Korea.
Gongyuan WeiSchool of Biology and Basic Medical Sciences, Soochow University, 199 Renai Road, Suzhou, 215123, People's Republic of China.
Seon-Won KimDivision of Applied Life Science (BK21 Plus), PMBBRC, Gyeongsang National University, 501 Jinju-daero, Jinju, 52828, Republic of Korea. swkim@gnu.ac.kr.

Funding

National Natural Science Foundation of China 21878198National Research Foundation of Korea NRF-2016R1A2B2010678Postdoctoral Research Foundation of China 2017M610350Rural Development Administration PJ01326501
6 · The paper itself

Abstract

Naturally occurring carotenoids have been isolated and used as colorants, antioxidants, nutrients, etc. in many fields. There is an ever-growing demand for carotenoids production. To comfort this, microbial production of carotenoids is an attractive alternative to current extraction from natural sources. This review summarizes the biosynthetic pathway of carotenoids and progresses in metabolic engineering of various microorganisms for carotenoid production. The advances in synthetic pathway and systems biology lead to many versatile engineering tools available to manipulate microorganisms. In this context, challenges and possible directions are also discussed to provide an insight of microbial engineering for improved production of carotenoids in the future.

Indexed as

Bacterial Physiological PhenomenaCarotenoidsMetabolic EngineeringMicroorganisms, Genetically-ModifiedCarotenoidsCarotenoidsMembrane engineeringSynthetic biologySystems biology

Identifiers

PMID30885243
PMCPMC6421696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.