ArticleJournal of translational medicine2019
Dermal tissue remodeling and non-osmotic sodium storage in kidney patients.
Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272841 (TransplantLines), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TransplantLines: the Transplantation Biobank
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Chronobiology of meal timing in early-stage hypertension: a controlled feeding pilot study investigating the effects on renal and vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Dietary Salt Intake and Hypertension in Chronic Kidney Disease.Electrolyte & blood pressure : E & BP · 2026Review
- Enhancing anti-neuroinflammation effect of X-ray-triggered RuFe-based metal-organic framework with dual enzyme-like activities.Frontiers in bioengineering and biotechnology · 2024Article
- Global, regional, and national burden of chronic kidney disease attributable to high sodium intake from 1990 to 2019.Frontiers in nutrition · 2023Article
- Reduction of Tissue NaKidney international reports · 2021Article
- Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus.JCI insight · 2021Article
- Direct Evidence of Endothelial Dysfunction and Glycocalyx Loss in Dermal Biopsies of Patients With Chronic Kidney Disease and Their Association With Markers of Volume Overload.Frontiers in cell and developmental biology · 2021Article
- High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.PloS one · 2021Article
- Inflammatory macrophages in the kidney contribute to salt-sensitive hypertension.American journal of physiology. Renal physiology · 2020Review
- Body Fluid-Independent Effects of Dietary Salt Consumption in Chronic Kidney Disease.Nutrients · 2019Review
- An observational study on intracutaneous sodium storage in intensive care patients and controls.PloS one · 2019Observational
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflammation and lymphangiogenesis. We aim to investigate if skin storage of sodium is increased in kidney patients and if this storage is associated with clinical parameters of sodium homeostasis and dermal tissue remodeling.
methodsAbdominal skin tissue of 12 kidney patients (5 on hemodialysis) and 12 healthy kidney donors was obtained during surgery. Skin biopsies were processed for dermal sodium measurement by atomic absorption spectroscopy, and evaluated for CD
resultsDermal sodium content of kidney patients did not differ from healthy individuals, but was inversely associated with plasma sodium values (p < 0.05). Compared to controls, kidney patients showed dermal tissue remodeling by increased CD
conclusionKidney patients did not show increased skin sodium storage compared to healthy individuals. Results do indicate that kidney failure associates with dermal inflammation, whereas increased sodium excretion and plasma sodium associate with dermal lymph vessel formation and loss of dermal sodium storage capacity. Trial registration The cohort is registered at clinicaltrials.gov as NCT (September 6, 2017). NCT, NCT03272841. Registered 6 September 2017-Retrospectively registered, https://clinicaltrials.gov.
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