ReviewJournal of translational medicine2019
Vitamin D and growth hormone in children: a review of the current scientific knowledge.
Review in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Association Between Vitamin D Status and Undernutrition Indices in Children: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in pediatrics · 2021Pooled it
- Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Association between postnatal anthropometric growth by term and high-performing neurodevelopment at age 3 years in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Relationship between inflammatory indicators and bone mineral density in preschool children.Pediatric research · 2026Article
- Beyond bones, vitamin D as a sunshine hormone in type 2 diabetes mellitus and its complications.iScience · 2026Review
- Vitamin D and hypoxia-inducible factors signaling interplay: A hypothesis-driven review of therapeutic strategies for acute cerebral infarction.Metabolic brain disease · 2026Review
- Effects of vitamin D supplementation under different salinities on hybrid red tilapia growth performance, hormonal profile and growth genes expression.Scientific reports · 2025Article
- Vitamin D Status in Children: Romania's National Vitamin D Screening Programme in Context of the COVID-19 Pandemic.Medical sciences (Basel, Switzerland) · 2025Observational
- Serum Levels of IL-6, IL-10, TNF-α, and Vitamin D: Their Correlation with Acute Otitis Media in Short-Stature Pediatric Patients.Journal of inflammation research · 2025Article
- Gender-Specific effects of L-arginine supplementation on bone mineral density and trabecular bone volume in Sprague-Dawley rats; stereological study.BMC complementary medicine and therapies · 2024Article
- Impact of vitamin D on hyperoxic acute lung injury in neonatal mice.BMC pulmonary medicine · 2024Article
- The interplay of immunity and growth: a case of combined variable immunodeficiency and growth hormone deficiency.Annals of medicine and surgery (2012) · 2024Article
- Vitamin D status and VDR gene polymorphisms in patients with growth hormone deficiency: A case control Tunisian study.Heliyon · 2024Article
- Deficient or Normal Growth Hormone Secretion in Polish Children with Short Stature: Searching for Clinical Differences.Biomedicines · 2024Article
- Vitamin D Maintains Growth and Bone Mineral Density against a Background of Severe Vitamin A Deficiency and Moderate Toxicity in a Swine Model.Nutrients · 2024Article
- Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2024Article
- Seasonal Variations in 25-Hydroxyvitamin D Levels among Pediatric Patients Attending the Healthcare Centre.Nutrients · 2024Article
- Age-dependent changes in plasma concentrations of 25-hydroxyvitamin D may complicate vitamin D status assessment of immature cats.Frontiers in veterinary science · 2024Article
- Social determinants of serum 25-hydroxyvitamin D concentrations deficiency in older Chilean people.Scientific reports · 2023Article
- IGF1 Genetic Polymorphism and the Association between Vitamin D Status and BMI Percentiles in Children.Children (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman growth is a complex mechanism that depends on genetic, environmental, nutritional and hormonal factors. The main hormone involved in growth at each stage of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). In contrast, vitamin D is involved in the processes of bone growth and mineralization through the regulation of calcium and phosphorus metabolism. Nevertheless, no scientific study has yet elucidated how they interact with one another, especially as a dysfunction in which one influences the other, even if numerous biochemical and clinical studies confirm the presence of a close relationship. MAIN BODY: We reviewed and analyzed the clinical studies that have considered the relationship between vitamin D and the GH/IGF-1 axis in pediatric populations. We found two main areas of interest: the vitamin D deficiency status in patients affected by GH deficit (GHD) and the relationship between serum vitamin D metabolites and IGF-1. Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.
conclusionsThese results could be followed by preventive interventions aimed at reducing the vitamin D deficit in pediatric age. In addition, further research is needed to fully understand how vitamin D and growth are intertwined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.