ArticleBMC plant biology2019
Two NCA1 isoforms interact with catalase in a mutually exclusive manner to redundantly regulate its activity in rice.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- A redox-regulated RCC1-like protein controls catalase activity in Arabidopsis.Nature communications · 2026Article
- Salinity Stress in Rice: Multilayered Approaches for Sustainable Tolerance.International journal of molecular sciences · 2025Review
- Recent Developments in CRISPR/Cas9 Genome-Editing Technology Related to Plant Disease Resistance and Abiotic Stress Tolerance.Biology · 2023Review
- The Molecular Chaperone Mechanism of the C-Terminal Domain of Large-Size Subunit Catalases.Antioxidants (Basel, Switzerland) · 2023Article
- Allelic variation of TaWD40-4B.1 contributes to drought tolerance by modulating catalase activity in wheat.Nature communications · 2023Article
- Engineering drought and salinity tolerance traits in crops through CRISPR-mediated genome editing: Targets, tools, challenges, and perspectives.Plant communications · 2022Review
- Large-Size Subunit Catalases Are Chimeric Proteins: A HAntioxidants (Basel, Switzerland) · 2022Article
- Reactive Oxygen Species, Antioxidant Responses and Implications from a Microbial Modulation Perspective.Biology · 2022Review
- Protein-protein interactions in plant antioxidant defense.Frontiers in plant science · 2022Review
- Genetic, Epigenetic, Genomic and Microbial Approaches to Enhance Salt Tolerance of Plants: A Comprehensive Review.Biology · 2021Review
- Catalase (CAT) Gene Family in Rapeseed (International journal of molecular sciences · 2021Article
- Two glyoxylate reductase isoforms are functionally redundant but required under high photorespiration conditions in rice.BMC plant biology · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNCA1 (NO CATALASE ACTIVITY 1) was recently identified in Arabidopsis as a chaperone protein to regulate catalase (CAT) activity through maintaining the folding of CAT. The gene exists mainly in higher plants; some plants, such as Arabidopsis, contain only one NCA1 gene, whereas some others such as rice harbor two copies. It is not yet understood whether and how both isoforms have functioned to regulate CAT activity in those two-copy-containing plant species.
resultsIn this study, we first noticed that the spatiotemporal expression patterns of NCA1a and NCA1b were very similar in rice plants. Subsequent BiFC and yeast three-hybrid experiments demonstrated that both NCA1a and NCA1b show mutually exclusive, rather than simultaneous, interaction with CAT. For a further functional analysis, nca1a and nca1b single mutants or double mutants of rice were generated by CRISPR/Cas9. Analysis on these mutants under both normal and salinity stress conditions found that, as compared with WT, either nca1a or nca1b single mutant showed no difference at phenotypes and CAT activities, whereas the double mutants constantly displayed very low CAT activity (about 5%) and serious lesion phenotypes.
conclusionsThese results suggest that NCA1a and NCA1b show mutually exclusive interaction with CAT to regulate CAT activity in a functionally-redundant manner in rice.
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