ArticleBMC neuroscience2019
Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy.
Article in BMC neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Biological current source imaging method based on acoustoelectric effect: A systematic review.Frontiers in neuroscience · 2022Pooled it
- Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition.Bioengineering (Basel, Switzerland) · 2025Review
- Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.Communications biology · 2025Article
- Shedding light on ultrasound in action: Optical and optoacoustic monitoring of ultrasound brain interventions.Advanced drug delivery reviews · 2024Review
- Narrative Review of Noninvasive Brain Stimulation in Stroke Rehabilitation.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders.Brain sciences · 2022Review
- Increasing the transmission efficiency of transcranial ultrasound using a dual-mode conversion technique based on Lamb waves.The Journal of the Acoustical Society of America · 2022Article
- Ultrasound as a Neurotherapeutic: A Circuit- and System-Based Interrogation.Focus (American Psychiatric Publishing) · 2022Review
- Multichannel near-infrared spectroscopy brain imaging system for small animals in mobile conditions.Neurophotonics · 2021Article
- Cell-type-specific bidirectional modulation of the cortico-thalamo-cortical sensory pathway by transcranial focused ultrasound (tFUS).Brain stimulationArticle
- Brain-wide hemodynamic responses to precise transcranial ultrasound neuromodulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner.
resultsThe results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave.
conclusionHigh frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change.
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Registered trials
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