Evidence map›Paper›PMID 30885117›Full record

ArticleBMC bioinformatics2019

GMASS: a novel measure for genome assembly structural similarity.

Daehong Kwon, Jongin Lee, Jaebum Kim

Abstract read
In one paragraph

Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daehong KwonDepartment of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, South Korea.
Jongin LeeDepartment of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, South Korea.
Jaebum KimDepartment of Biomedical Science and Engineering, Konkuk University, Seoul, 05029, South Korea. jbkim@konkuk.ac.kr.ORCID http://orcid.org/0000-0002-2287-9760

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThanks to the recent advancements in next-generation sequencing (NGS) technologies, large amount of genomic data, which are short DNA sequences known as reads, has been accumulating. Diverse assemblers have been developed to generate high quality de novo assemblies using the NGS reads, but their output is very different because of algorithmic differences. However, there are not properly structured measures to show the similarity or difference in assemblies.

resultsWe developed a new measure, called the GMASS score, for comparing two genome assemblies in terms of their structure. The GMASS score was developed based on the distribution pattern of the number and coverage of similar regions between a pair of assemblies. The new measure was able to show structural similarity between assemblies when evaluated by simulated assembly datasets. The application of the GMASS score to compare assemblies in recently published benchmark datasets showed the divergent performance of current assemblers as well as its ability to compare assemblies.

conclusionThe GMASS score is a novel measure for representing structural similarity between two assemblies. It will contribute to the understanding of assembly output and developing de novo assemblers.

Indexed as

Genome, HumanGenomicsDatabases, GeneticHigh-Throughput Nucleotide SequencingHumansModels, TheoreticalMolecular StructureSequence Analysis, DNAAssemblyGenomeMeasureStructural similarity

Identifiers

PMID30885117
PMCPMC6423833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.