ArticleHematology (Amsterdam, Netherlands)2019
Diagnostic and therapeutic splenectomy for splenic lymphomas: analysis of the National Cancer Data Base.
Article in Hematology (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A case of methotrexate-associated primary splenic lymphoma diagnosed by endoscopic biopsy of a small gastric lesion.Clinical journal of gastroenterology · 2026Article
- Case Report: Ultrasound-guided percutaneous splenic biopsy as a lifesaving diagnostic modality in B-cell lymphoma presenting as hemophagocytic lymphohistiocytosis: a report of two cases.Frontiers in oncology · 2026Article
- Primary Splenic Follicular Lymphoma Presenting As Isolated Splenomegaly: A Case Report.Cureus · 2025Article
- Splenectomy in Onco-Hematologic Patients: A Retrospective Study of Early Complications and 1-Year Mortality.Cancers · 2025Article
- Clinical and Diagnostic Challenges in Primary Splenic Lymphomas: When is Splenectomy Necessary to Differentiate SMZL from DLBCL?European journal of case reports in internal medicine · 2025Article
- Tonsillar Diffuse Large B-Cell Lymphoma of Non-Germinal Center Type With Cluster of Differentiation 5 Positive in a Pediatric Girl.Journal of medical cases · 2024Article
- Splenic cyst deroofing complicated with B lymphoma.World journal of surgical oncology · 2024Article
- Machine Learning Radiomics Signature for Differentiating Lymphoma versus Benign Splenomegaly on CT.Diagnostics (Basel, Switzerland) · 2023Article
- [Splenic surgery in hematological diseases : Indications and surgical technique].Chirurgie (Heidelberg, Germany) · 2023Review
- Prognostic nomogram for primary splenic lymphoma: a SEER database-based study.American journal of cancer research · 2023Article
- Clinical benefit of R-CHOP without splenectomy in stage I primary splenic diffuse large B-cell lymphoma.BMJ case reports · 2022Article
- CD5-Negative, CD10-Negative Low-Grade B-Cell Lymphoproliferative Disorders of the Spleen.Current oncology (Toronto, Ont.) · 2021Review
- Low-Grade Primary Splenic CD10-Positive Small B-Cell Lymphoma/Follicular Lymphoma.Current oncology (Toronto, Ont.) · 2021Review
- How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.Current oncology (Toronto, Ont.) · 2021Review
- Reappraisal of surgical decision-making in patients with splenic sclerosing angiomatoid nodular transformation: Case series and literature review.World journal of gastrointestinal surgery · 2021Article
- [Clinical features and treatment outcome of patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2021Article
- Diagnostic Splenectomy: Characteristics, Pre-Operative Investigations, and Identified Pathologies for 20 Patients.Journal of clinical medicine · 2021Article
- Tumor Immune Evasion Induced by Dysregulation of Erythroid Progenitor Cells Development.Cancers · 2021Review
- How we treat mature B-cell neoplasms (indolent B-cell lymphomas).Journal of hematology & oncology · 2021Review
- The Diagnostic Utility of Splenectomy in Idiopathic Splenomegaly.World journal of surgery · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the use of splenectomy, chemotherapy, and subsequent overall survival (OS) in contemporary patients with splenic lymphomas.
methodsWe analyzed records of 6450 patients with various splenic lymphomas recorded in the National Cancer Data Base (2004-2013). Survival was compared using Mantel-Byer test to account for guarantee-time bias, stratified by age, sex, comorbidities, and lymphoma stage.
resultsSplenectomy rate was overall 58%, and varied from 49% in splenic marginal zone (SMZL) to 77% in follicular lymphoma (FL). It significantly decreased across all histologies over time (overall from 69% in 2004, to 44% in 2013). Thirty-day mortality after splenectomy was 4%. Chemotherapy use varied from 40% in FL to 76% in diffuse large B-cell lymphoma (DLBCL), but increased significantly only for SMZL and T-cell lymphomas over time. Overall, 57% of splenectomies were performed as diagnostic procedures, which was significantly less common in academic hospitals (p < 0.0001). Following a diagnostic splenectomy, chemotherapy was not administered to 29% of patients with DLBCL, 49% with mantle cell, and 42% with T-cell lymphomas. Median OS ranged from 12.4 years for FL to 1.0 year for T-cell lymphomas. We found no association between performance of splenectomy and OS across all histologies. Patients with DLBCL who did not receive chemotherapy after a diagnostic splenectomy had significantly worse OS (p = 0.001). The association between post-splenectomy chemotherapy and OS was not observed in FL or SMZL.
conclusionmany splenic lymphomas may be treated without surgery, but a high proportion of diagnostic splenectomies indicates an ongoing need for less invasive diagnostic modalities.
Indexed as
Identifiers
30885066PMC6425967W2922956176What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.