SynthesisInternational journal of molecular sciences2019
Autologous Platelet Concentrates in Treatment of Furcation Defects-A Systematic Review and Meta-Analysis.
Synthesis in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Periodontal regeneration using platelet-rich fibrin. Furcation defects: A systematic review with meta-analysis.Periodontology 2000 · 2025Pooled it
- Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Pooled it
- [Effect of concentrated growth factors in guided tissue regeneration for the treatment of mandibular molar furcation lesions].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Trial
- The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study.PloS one · 2024Trial
- Effect of Pre-Orthodontic CGF-Assisted GTR for Class II Furcation Lesions After Orthodontic Treatment: 5-Year Observation.International dental journal · 2026Article
- Platelet derivatives in oral and maxillofacial surgery: classification, and clinical applications.Frontiers in cell and developmental biology · 2026Review
- A comparative evaluation of eggshell derived hydroxyapatite and demineralized freeze-dried bone allograft in alveolar ridge preservation - a randomized clinical trial.Biomaterial investigations in dentistry · 2025Article
- Exosomes derived from platelet-rich plasma present a novel potential in repairing knee articular cartilage defect combined with cyclic peptide-modified β-TCP scaffold.Journal of orthopaedic surgery and research · 2024Article
- Comprehensive analysis of L-PRF exudate components and their impact on whole blood platelets.Clinical oral investigations · 2024Article
- Review
- Estimation of Cancellous Changes Using Fractal Analysis in Patients with Periodontitis.Biomedicines · 2023Article
- Effectiveness of Hyaluronic Acid Gel Injection with and without PRGF for Management of Interdental Papillary Loss: A Randomized Clinical Trial.Journal of functional biomaterials · 2023Article
- Effect of Injectable Platelet-Rich Fibrin with a Nano-Hydroxyapatite Bone Graft on the Treatment of a Grade II Furcation Defect.Bioengineering (Basel, Switzerland) · 2022Article
- Article
- Clinical and Radiographic Evaluation of Applying Atorvastatin 1.2% Bio Adhesive with Plasma Rich in Growth Factor (PRGF) for Treatment of Mandibular Class II Furcation Defects: a Randomized Clinical Trial.Journal of dentistry (Shiraz, Iran) · 2022Article
- Overview of the Effect of Different Regenerative Materials in Class II Furcation Defects in Periodontal Patients.Materials (Basel, Switzerland) · 2022Review
- The Adjunctive Use of Leucocyte- and Platelet-Rich Fibrin in Periodontal Endosseous and Furcation Defects: A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2022Review
- Platelets' Role in Dentistry: From Oral Pathology to Regenerative Potential.Biomedicines · 2022Review
- Early Optimistic Effect in Periodontology and Implant Dentistry Trials.Journal of dental research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment.
methodsA systematic search was carried out in the electronic databases MEDLINE, SCOPUS, CENTRAL (Cochrane Central Register of Controlled Trials), and EMBASE, together with hand searching of relevant journals. Two independent reviewers screened the articles yielded in the initial search and retrieved the full-text version of potentially eligible studies. Relevant data and outcomes were extracted from the included studies. Risk of bias assessment was also carried out. The outcome variables, relative to baseline and post-operative defect characteristics (probing pocket depth (PPD), horizontal and vertical clinical attachment loss (HCAL, VCAL), horizontal and vertical furcation depth (HFD, VFD) were considered for meta-analysis.
resultsTen randomized trials were included in this review. Only one study was judged at high risk of bias, while seven had a low risk, testifying to the good level of the evidence of this review. The meta-analysis showed a favorable effect regarding all outcome variables, for APCs used in adjunct to open flap debridement (
conclusionFor the treatment of furcation defects APCs may be beneficial as an adjunct to open flap debridement alone and bone grafting, while limited evidence of an effect of APCs when used in combination with GTR was found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.