Evidence map›Paper›PMID 30884850›Full record

ReviewMarine drugs2019

Antithrombotics from the Sea: Polysaccharides and Beyond.

Francisca Carvalhal, Ricardo R Cristelo, Diana I S P Resende, Madalena M M Pinto, Emília Sousa, Marta Correia-da-Silva

Abstract readReview
In one paragraph

Review in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Review
  3. Chemical Structure of a Branched α-d-Glucan from the Eggs of Sea UrchinInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. A 70% EthanolMolecules (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Antiviral Activity ofCurrent topics in medicinal chemistry · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Marine Natural Products and Coronary Artery Disease.Frontiers in cardiovascular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francisca CarvalhalLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. francisca.carvalhal@gmail.com.
Ricardo R CristeloLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. ricardorc@live.com.pt.
Diana I S P ResendeLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. dresende@ff.up.pt.ORCID 0000-0002-4077-6060
Madalena M M PintoLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.ORCID 0000-0002-4676-1409
Emília SousaLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. esousa@ff.up.pt.ORCID 0000-0002-5397-4672
Marta Correia-da-SilvaLQOF-Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. m_correiadasilva@ff.up.pt.ORCID 0000-0003-4150-8532

Funding

Fundação para a Ciência e a Tecnologia PTDC/AAGTEC/0739/2014, PTDC/MAR-BIO/4694/2014, POCI-01-0145-FEDER-028736
6 · The paper itself

Abstract

Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.

Indexed as

AnimalsAnticoagulantsAquatic OrganismsFibrinolytic AgentsPolysaccharidesStructure-Activity RelationshipAnticoagulantsFibrinolytic AgentsPolysaccharidesanticoagulantantiplateletantithromboticglycosaminoglycansmarine-derivedpolysaccharidesulfated fucanssulfated galactans

Identifiers

PMID30884850
PMCPMC6471875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.