ArticleNutrients2019
Homocysteine Metabolism in Children and Adolescents: Influence of Age on Plasma Biomarkers and Correspondent Genotype Interactions.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association Between MTHFR C677T Polymorphism and Susceptibility to Autism Spectrum Disorders: A Meta-Analysis in Chinese Han Population.Frontiers in pediatrics · 2021Pooled it
- Trial
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- Pilot Newborn Screening for Vitamin B12 Deficiency in the Czech Republic: Results and Detailed Studies on Identified Babies and Their Mothers.International journal of neonatal screening · 2026Article
- Low vitamin D and folate levels are associated with costochondritis: a retrospective cross-sectional study on children with impaired bone health.BMC pediatrics · 2026Article
- Evaluation of Total Homocysteine Levels in Relation to Abdominal Fat Mass and Traditional Cardiovascular Risk Factors in Overweight and Obese Adolescents.Life (Basel, Switzerland) · 2025Article
- Article
- Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations.Journal of clinical medicine · 2023Article
- Consumption of very low-mineral water may threaten cardiovascular health by increasing homocysteine in children.Frontiers in nutrition · 2023Article
- SARS-CoV-2 Infection: What Is Currently Known about Homocysteine Involvement?Diagnostics (Basel, Switzerland) · 2022Review
- Distribution and Determinants of Plasma Homocysteine Levels in a Preconception Population: A Retrospective Single-Center Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection.Nutrients · 2022Article
- Serum homocysteine level in pediatric patients with COVID-19 and its correlation with the disease severity.Pediatric pulmonology · 2022Article
- Estradiol and Hyperhomocysteinemia Are Linked Predominantly Through Part Renal Function Indicators.Frontiers in endocrinology · 2022Article
- The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study.Acta diabetologica · 2021Article
- Folate and Cobalamin Serum Levels in Healthy Children and Adolescents and Their Association with Age, Sex, BMI and Socioeconomic Status.Nutrients · 2021Article
- Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.International journal of molecular sciences · 2020Review
- Scutellarin Reduce the Homocysteine Level and Alleviate Liver Injury in Type 2 Diabetes Model.Frontiers in pharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImbalance of homocysteine (Hcy) metabolism links with several pathologies; nevertheless, it is poorly characterized in pediatric populations. This study investigated the impact of age on plasma concentrations of Hcy and relevant biomarkers along with correspondent genotype interactions.
methodsA healthy pediatric cohort aged 9 (
resultsAge impacted on levels of Hcy and metabolic markers: older children presented with the lowest folates and total-cobalamin (tCbl), while with the highest Hcy concentrations, whereas methylmalonic acid (MMA) and holotranscobalamin (Holo-TC) levels remained similar in 9-yo and 17-yo children. The relationships between B-vitamins and metabolic markers were also dependent on age. Only in the older children, MMA correlated with tCbl and Holo-TC, and MMA levels were markedly higher in the 17-yo subjects presenting with the lowest quartiles of Holo-TC concentrations. Lastly, age also impacted on the correlations between genotype and biomarkers. In the 17-yo group, however not in the 9-yo children, tHcy differed between
conclusionsAge impacts on the Hcy metabolism dynamics in a pediatric population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.