ReviewNutrients2019
Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project.Nutrition & diabetes · 2023Pooled it
- The effect of high-fructose corn syrup vs. sucrose on anthropometric and metabolic parameters: A systematic review and meta-analysis.Frontiers in nutrition · 2022Pooled it
- Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights.Nature metabolism · 2025Trial
- Synthetic Sweeteners and Human Health: An Overview of Health Risks, Vulnerable Populations, and Effects on Key Biological Systems.Medicina (Kaunas, Lithuania) · 2026Review
- Artificial sweeteners and risk of cardiometabolic outcomes and mortality: a systematic review and meta-analysis.Nutrition research and practice · 2026Review
- Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders.Nutrients · 2026Review
- Aspartame and Human Health: A Mini-Review of Carcinogenic and Systemic Effects.Journal of xenobiotics · 2025Review
- The Antioxidative, Anti-inflammatory and Anti-apoptotic Effects of Tetrapleura Tetraptera (Aidan) Ethanol Leaf Extract in the Brain of Wistar Rats Exposed to Aspartame.Molecular neurobiology · 2025Article
- Ultra-processed foods and type 2 diabetes mellitus incidence in RaNCD project: a prospective cohort study.Acta diabetologica · 2025Article
- Association of non-nutritive sweetener consumption with food craving and body image among university students: A cross-sectional study.PloS one · 2025Article
- Edible evolution: the significance of food additives in shaping human health.Frontiers in nutrition · 2025Review
- Additives in foods marketed to children in Uruguay, an emerging Latin American country.Journal of nutritional science · 2025Article
- Chronic Use of Artificial Sweeteners: Pros and Cons.Nutrients · 2024Review
- Article
- Article
- Alteration of oral microbial biofilms by sweeteners.Biofilm · 2024Review
- Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides: Fast Food-Induced Obesity Perspective-A Narrative Review.Biomolecules · 2024Review
- Sucralose: From Sweet Success to Metabolic Controversies-Unraveling the Global Health Implications of a Pervasive Non-Caloric Artificial Sweetener.Life (Basel, Switzerland) · 2024Review
- Artificial sweeteners and their implications in diabetes: a review.Frontiers in nutrition · 2024Review
- Learning and memory deficits produced by aspartame are heritable via the paternal lineage.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Individuals widely use non-nutritive sweeteners (NNS) in attempts to lower their overall daily caloric intake, lose weight, and sustain a healthy diet. There are insufficient scientific data that support the safety of consuming NNS. However, recent studies have suggested that NNS consumption can induce gut microbiota dysbiosis and promote glucose intolerance in healthy individuals that may result in the development of type 2 diabetes mellitus (T2DM). This sequence of events may result in changes in the gut microbiota composition through microRNA (miRNA)-mediated changes. The mechanism(s) by which miRNAs alter gene expression of different bacterial species provides a link between the consumption of NNS and the development of metabolic changes. Another potential mechanism that connects NNS to metabolic changes is the molecular crosstalk between the insulin receptor (IR) and G protein-coupled receptors (GPCRs). Here, we aim to highlight the role of NNS in obesity and discuss IR-GPCR crosstalk and miRNA-mediated changes, in the manipulation of the gut microbiota composition and T2DM pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.