Evidence map›Paper›PMID 30884806›Full record

ReviewInternational journal of molecular sciences2019

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.

Alessandra Ventura, Cristina Pellegrini, Ludovica Cardelli, Tea Rocco, Valeria Ciciarelli, Ketty Peris, Maria Concetta Fargnoli

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Assessment of telomerase expression in melanoma and cutaneous squamous cell carcinoma: correlation with clinical parameters.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Observational
  5. Article
  6. Article
  7. Review
  8. Telomeres and telomerase in Sarcoma disease and therapy.International journal of medical sciences · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Non-Melanoma Skin Cancers: Biological and Clinical Features.International journal of molecular sciences · 2020
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alessandra VenturaDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. alessandraventura@live.it.
Cristina PellegriniDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. cristina.pellegrini@cc.univaq.it.ORCID 0000-0003-2168-8097
Ludovica CardelliDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. ludovica.cardelli@graduate.univaq.it.
Tea RoccoDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. tearocco@gmail.com.
Valeria CiciarelliDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. valeria.ciciarelli@hotmail.it.
Ketty PerisInstitute of Dermatology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, 00186 Rome, Italy. Ketty.Peris@unicatt.it.
Maria Concetta FargnoliDepartment of Dermatology, Department of Applied Clinical Sciences and Biotechnologies, University of L'Aquila, 67100 L'Aquila, Italy. mariaconcetta.fargnoli@univaq.it.
University of L'Aquila · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of telomere biology and telomerase activation in skin cancers has been investigated in melanoma and basal cell carcinoma but limited evidence is available for cutaneous squamous cell carcinoma (cSCC). We will review the current knowledge on the role of telomere and telomerase pathway in cSCC pathogenesis. At the somatic level, both long and short telomere lengths have been described in cSCC. This telomere dichotomy is probably related to two different mechanisms of tumour initiation which determines two tumour subtypes. Telomere shortening is observed during the invasive progression from in situ forms of cSCC, such as Bowen's disease (BD) and actinic keratosis (AK), to invasive cSCC. At the germline level, controversial results have been reported on the association between constitutive telomere length and risk of cSCC. Approximately 75⁻85% of cSCC tumours are characterized by a high level of telomerase activity. Telomerase activation has been also reported in AKs and BD and in sun-damaged skin, thus supporting the hypothesis that UV modulates telomerase activity in the skin. Activating

Indexed as

Bowen's DiseaseCarcinoma, Squamous CellDisease ProgressionGerm CellsHumansKeratosis, ActinicMutationSkin NeoplasmsTelomeraseTelomereTelomere ShorteningTelomerasecutaneous squamous cell carcinomatelomerasetelomereTERT promoter

Identifiers

PMID30884806
PMCPMC6470499
OpenAlexW2921575851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.