Evidence map›Paper›PMID 30884786›Full record

ReviewPharmaceutics2019

Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy.

Courtney van Ballegooie, Alice Man, Mi Win, Donald T Yapp

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Recent advances in liposome formulations for breast cancer therapeutics.Cellular and molecular life sciences : CMLS · 2021
    Review
  7. Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review.ACS pharmacology & translational science · 2021
    Review
  8. Article
  9. Ultrasound-Triggered Enzymatic Gelation.Advanced materials (Deerfield Beach, Fla.) · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Courtney van BallegooieExperimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, Canada. cballegooie@bccrc.ca.
Alice ManFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. aliceman321@gmail.com.
Mi WinDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. mi_mu_mu_win@sfu.ca.
Donald T YappExperimental Therapeutics, BC Cancer, Vancouver, BC V5Z 1L3, Canada. dyapp@bccrc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment's formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed.

Indexed as

liposomesmagnetic fieldsradiationtriggered drug releaseultrasound

Identifiers

PMID30884786
PMCPMC6470770

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.