Evidence map›Paper›PMID 30884371›Full record

ArticleJournal of affective disorders2019

Depression and aging with HIV: Associations with health-related quality of life and positive psychological factors.

Alexandra S Rooney, Raeanne C Moore, Emily W Paolillo, Ben Gouaux, Anya Umlauf, Scott L Letendre, Dilip V Jeste, David J Moore, HIV Neurobehavioral Research Program

Abstract readComparative Study
In one paragraph

Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Geographic Patterns of Human Immunodeficiency Virus (HIV) Risk Behaviors Among Older Adults: A Strategy for Identifying Space as a Risk Exposure.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra S RooneyDepartment of Psychiatry, University of California San Diego, USA.
Raeanne C MooreDepartment of Psychiatry, University of California San Diego, USA; Stein Institute for Research on Aging, University of California San Diego, USA; Veterans Administration San Diego Health Care System, San Diego, USA.
Emily W PaolilloSDSU/UCSD Joint Doctoral Program in Clinical Psychology, USA.
Ben GouauxDepartment of Psychiatry, University of California San Diego, USA.
Anya UmlaufDepartment of Psychiatry, University of California San Diego, USA.
Scott L LetendreDepartment of Medicine, University of California San Diego, USA.
Dilip V JesteDepartment of Psychiatry, University of California San Diego, USA; Stein Institute for Research on Aging, University of California San Diego, USA; Department of Neuroscience, University of California San Diego, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, USA. Electronic address: djmoore@ucsd.edu.
HIV Neurobehavioral Research Program

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Alcohol Research in the Science/Practitioner ModelT32AA013525 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY, ANDREA SPADONI TOWNSEND · 2002 to 2026
$8.4M
Detect: A novel device to assess how HIV affects neurocognitive decline and postural instability in older adults at risk for Alzheimer's DiseaseR01AG062387 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2019 to 2023
$3.9M
Multi-Dimensional Successful Aging Among HIV-Infected AdultsR01MH099987 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JESTE, DILIP V., MOORE, DAVID J · 2013 to 2019
$3.8M
Real-Time Mobile Assessment of Daily Functioning Among Older HIV-Infected AdultsK23MH107260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, RAEANNE CRISTINE · 2015 to 2018
$927k
NIAAA NIH HHS T32 AA013525NIA NIH HHS R01 AG062387NIMH NIH HHS K23 MH107260NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH099987
6 · The paper itself

Abstract

backgroundDepression is prevalent among persons living with HIV (PLWH). This study investigated the relationships between depressive symptomatology, health-related quality of life (HRQoL), and positive psychological factors in PLWH and age-matched HIV-individuals.

methodsOne hundred twenty-two PLWH and 94 HIV- individuals, recruited in three age cohorts (36-45, 46-55, 56-65 years old), completed self-report questionnaires on depressive symptoms (CES-D), HRQoL, and positive psychological factors (resilience, grit, and self-rated successful aging [SRSA]). Participants were classified based on HIV status (H+ vs H-) and elevated depressive symptoms (D+ vs D-) into four groups (H+/D+; H-/D+; H+/D-; H-/D-).

resultsFifty-eight percent of PLWH had elevated depressive scores, compared to 33% of HIV- individuals (p < 0.001). The proportion of individuals reporting elevated depressive symptoms only differed among individuals 36-45 years old (H+: 61.5%; H-: 17.9%; p < 0.001). Individuals in the H+/D+ group reported the lowest HRQoL, resilience, grit, and SRSA across age cohorts. However, there were no differences on HRQoL or positive psychological factors between H+/D- and H-/D- groups; in fact, individuals 56-65 years in the H+/D- group endorsed aging the most successfully. LIMITATIONS: Small sample size within the groups and the cross-sectional nature of the analysis limit the ability to address onset of depressive symptoms in relation to HRQoL or positive psychological factors.

conclusionsAmong PLWH depressive symptoms show a strong association with HRQoL and positive psychological factors compared to HIV- individuals. In the absence of elevated depressive symptoms, however, PLWH report similar HRQoL and positive psychological factors to HIV- individuals.

Indexed as

AdultAgedAgingCross-Sectional StudiesDepressive DisorderFemaleFollow-Up StudiesHealth StatusHIV InfectionsHumansMaleMiddle AgedQuality of LifeSelf ReportSubstance-Related DisordersSurveys and Questionnaires

Identifiers

PMID30884371
PMCPMC6705595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.