Trial reportPsychiatry research2019
Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study.
Open access · greenAbstract readClinical Trial
In one paragraph
Trial report in Psychiatry research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Glutamatergic Modulation of Brain Function in Psychosis: A Systematic Review of Neuroimaging Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Pooled it
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Frontal neural metabolite changes in schizophrenia and their association with cognitive control: A systematic review.Neuroscience and biobehavioral reviews · 2022Pooled it
- Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis ofMolecular psychiatry · 2022Pooled it
- Response to Intravenous N-Acetylcysteine Supplementation in Critically Ill Patients with COVID-19.Nutrients · 2023Trial
- Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer's disease.Brain : a journal of neurology · 2021Trial
- From Damage to Dysregulation: Reframing Oxidative Stress and Redox Homeostasis in Central Nervous System Disease.International journal of molecular sciences · 2026Review
- Article
- Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy in Health and Disease.bioRxiv : the preprint server for biology · 2023Article
- Challenges and Strategies for the Recruitment of Patients With Schizophrenia in a Research Setting.The international journal of neuropsychopharmacology · 2022Article
- Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.Neurotoxicity research · 2022Article
- Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?Antioxidants (Basel, Switzerland) · 2021Review
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia.Molecular psychiatry · 2021Article
- Glutathione in the Brain.International journal of molecular sciences · 2021Review
- The potential ofPsychopharmacology · 2021Review
- Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine.Translational psychiatry · 2019Article
- Striatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy.Archives of medical research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Ragy R GirgisDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA. Electronic address: ragy.girgis@nyspi.columbia.edu.
Seth BakerDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Xiangling MaoDepartment of Radiology, Weill Cornell Medical College, New York, USA.
Roberto GilDepartment of Psychiatry, Stony Brook University School of Medicine, Stony Brook, USA.
Daniel C JavittDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Joshua T KantrowitzDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Meng GuDepartment of Radiology, Stanford University, Stanford, CA, USA.
Daniel M SpielmanDepartment of Radiology, Stanford University, Stanford, CA, USA.
Najate OjeilDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Xiaoyan XuDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Anissa Abi-DarghamDepartment of Psychiatry, Stony Brook University School of Medicine, Stony Brook, USA.
Dikoma C ShunguDepartment of Radiology, Weill Cornell Medical College, New York, USA.
Lawrence S KegelesDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
New York State Psychiatric InstituteCornell University · USStanford University · USStony Brook University · US
Funding
Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7MBiomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7MNovel MRS Neurotechnology for Imaging GABA & Glutamate Function in SchizophreniaR01MH075895 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHUNGU, DIKOMA C · 2007 to 2011
$2.3M3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0MSpecificity and Validity of Oxidative Stress Model of Chronic Fatigue SyndromeR01MH100005 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHUNGU, DIKOMA C · 2013 to 2016
$2.0MRobust 1H MRSI of GABA, Glutamate, Glutamine, and Glutathione R01MH110683 · NIMH · STANFORD UNIVERSITY · PI SPIELMAN, DANIEL M · 2017 to 2020
$1.5MNeurochemical and Clinical Effects of Glutamate Modulation in SchizophreniaR21MH099508 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2014 to 2015
$455kNIBIB NIH HHS P41 EB015891NIH HHS S10 OD021782NIMH NIH HHS R01 MH075895NIMH NIH HHS R01 MH100005NIMH NIH HHS R01 MH110270NIMH NIH HHS R01 MH110683NIMH NIH HHS R21 MH099508
Abstract
Findings from in vivo brain proton magnetic resonance spectroscopy (
Indexed as
AcetylcysteineAdolescentAdultFemaleFree Radical ScavengersGlutamic AcidGlutathioneGyrus CinguliHumansMaleMiddle AgedPrefrontal CortexProton Magnetic Resonance SpectroscopySchizophreniaYoung AdultAcetylcysteineFree Radical ScavengersGlutamic AcidGlutathioneGlutamateGlutathioneMagnetic resonance spectroscopyN-acetylcysteineSchizophrenia
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.