Evidence map›Paper›PMID 30884215›Full record

ArticleBrain and behavior2019

Assessment of dynamic functional connectivity in resting-state fMRI using the sliding window technique.

Antonis D Savva, Georgios D Mitsis, George K Matsopoulos

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Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

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45citing papers in PubMed
–field-weighted citation impact
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3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Antonis D SavvaSchool of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.ORCID 0000-0002-0056-5680
Georgios D MitsisDepartment of Bioengineering, McGill University, Montreal, Quebec, Canada.
George K MatsopoulosSchool of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecent studies related to assessing functional connectivity (FC) in resting-state functional magnetic resonance imaging have revealed that the resulting connectivity patterns exhibit considerable fluctuations (dynamic FC [dFC]). A widely applied method for quantifying dFC is the sliding window technique. According to this method, the data are divided into segments with the same length (window size) and a correlation metric is employed to assess the connectivity within these segments, whereby the window size is often empirically chosen.

methodsIn this study, we rigorously investigate the assessment of dFC using the sliding window approach. Specifically, we perform a detailed comparison between different correlation metrics, including Pearson, Spearman and Kendall correlation, Pearson and Spearman partial correlation, Mutual Information (MI), Variation of Information (VI), Kullback-Leibler divergence, Multiplication of Temporal Derivatives and Inverse Covariance.

resultsUsing test-retest datasets, we show that MI and VI yielded the most consistent results by achieving high reliability with respect to dFC estimates for different window sizes. Subsequent hypothesis testing, based on multivariate phase randomization surrogate data generation, allowed the identification of dynamic connections between the posterior cingulate cortex and regions in the frontal lobe and inferior parietal lobes, which were overall in agreement with previous studies.

conclusionsIn the case of MI and VI, a window size of at least 120 s was found to be necessary for detecting dFC for some of the previously identified dynamically connected regions.

Indexed as

BrainBrain MappingFunctional NeuroimagingHumansMagnetic Resonance ImagingReproducibility of Resultsfunctional connectivity metricsinformation based metricsMultiplication of Temporal Derivativespartial correlation metricssurrogate datawindow size

Identifiers

PMID30884215
PMCPMC6456784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.