Evidence map›Paper›PMID 30883986›Full record

Trial reportPsycho-oncology2019

A randomized controlled intervention to promote readiness to genetic counseling for breast cancer survivors.

Monica L Kasting, Claire C Conley, Aasha I Hoogland, Courtney L Scherr, Jongphil Kim, Ram Thapa, Maija Reblin, Cathy D Meade, M Catherine Lee, Tuya Pal and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psycho-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Article
  9. Assessing relatives' readiness for hereditary cancer cascade genetic testing.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monica L KastingDepartment of Health and Kinesiology, Purdue University, West Lafayette, Indiana.ORCID 0000-0002-9879-7235
Claire C ConleyDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0001-7695-2428
Aasha I HooglandDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-8691-8132
Courtney L ScherrDepartment of Communication Studies, Northwestern University, Evanston, Illinois.ORCID 0000-0001-9362-5410
Jongphil KimDivision of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-7430-2226
Ram ThapaDivision of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida.
Maija ReblinDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0003-3108-465X
Cathy D MeadeDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.
M Catherine LeeComprehensive Breast Program, Moffitt Cancer Center, Tampa, Florida.
Tuya PalDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0001-8009-2475
Gwendolyn P QuinnDepartment of Obstetrics and Gynecology, New York University, New York, New York.ORCID 0000-0002-4208-9889
Susan T VadaparampilDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-1052-6917

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Behavioral Oncology Education & Career DevelopmentR25CA090314 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI BRANDON, THOMAS H · 2003 to 2018
$4.0M
Genetic Education to Promote Counseling Attendance after Surgical Treatment (GETR21HG006415 · NHGRI · H. LEE MOFFITT CANCER CTR & RES INST · PI VADAPARAMPIL, SUSAN T · 2011 to 2012
$459k
Infection and Cancer Research: A New Frontier in Cancer Prevention and ControlK05CA181320 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GIULIANO, ANNA R. · 2014 to 2018
$431k
NCI NIH HHS 5P30CA076292NCI NIH HHS K05 CA181320NCI NIH HHS K05-CA181320NCI NIH HHS P30 CA076292NCI NIH HHS R25 CA090314NCI NIH HHS R25-CA090314NHGRI NIH HHS 1 R21 HG006415NHGRI NIH HHS R21 HG006415NIH HHS 5P30CA076292
6 · The paper itself

Abstract

objectiveBreast cancer (BC) survivors with a genetic mutation are at higher risk for subsequent cancer; knowing genetic risk status could help survivors make decisions about follow-up screening. Uptake of genetic counseling and testing (GC/GT) to determine BRCA status is low among high risk BC survivors. This study assessed feasibility, acceptability, and preliminary efficacy of a newly developed psychoeducational intervention (PEI) for GC/GT.

methodsHigh risk BC survivors (N = 119) completed a baseline questionnaire and were randomized to the intervention (PEI video/booklet) or control (factsheet) group. Follow-up questionnaires were completed 2 weeks after baseline (T2), and 4 months after T2 (T3). We analyzed recruitment, retention (feasibility), whether the participant viewed study materials (acceptability), intent to get GC/GT (efficacy), and psychosocial outcomes (eg, perceived risk, Impact of Events Scale [IES]). t tests or chi-square tests identified differences between intervention groups at baseline. Mixed models examined main effects of group, time, and group-by-time interactions.

resultsGroups were similar on demographic characteristics (P ≥ .05). Of participants who completed the baseline questionnaire, 91% followed through to study completion and 92% viewed study materials. A higher percentage of participants in the intervention group moved toward GC/GT (28% vs 8%; P = .027). Mixed models demonstrated significant group-by-time interactions for perceived risk (P = .029), IES (P = .027), and IES avoidance subscale (P = .012).

conclusionsThe PEI was feasible, acceptable, and efficacious. Women in the intervention group reported greater intentions to pursue GC, greater perceived risk, and decreased avoidance. Future studies should seek to first identify system-level barriers and facilitators before aiming to address individual-level barriers.

Indexed as

Patient SatisfactionAdultBreast NeoplasmsCancer SurvivorsDecision MakingFemaleGenetic CounselingGenetic TestingHumansMass ScreeningMiddle AgedPamphletsRisk FactorsSurveys and QuestionnairesBRCAcancereducational interventiongenetic counselinggenetic testinghereditary breast canceroncologystages of change

Identifiers

PMID30883986
PMCPMC6873464

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.