Evidence map›Paper›PMID 30883723›Full record

ArticleEuropean journal of immunology2019

Expression of IL-7Rα and KLRG1 defines functionally distinct CD8

Ester B M Remmerswaal, Pleun Hombrink, Benjamin Nota, Hanspeter Pircher, Ineke J M Ten Berge, René A W van Lier, Michiel C van Aalderen

Open access · hybridAbstract read
In one paragraph

Article in European journal of immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Polyfunctional CD8Molecular oncology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. The role of KLRG1: a novel biomarker and new therapeutic target.Cell communication and signaling : CCS · 2024
    Review
  11. Article
  12. Single-cell analysis of the CD8Haematologica · 2024
    Article
  13. Article
  14. Depletion of polyfunctional CD26Experimental hematology & oncology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. How to Reliably Define Human CD8Cold Spring Harbor perspectives in biology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ester B M RemmerswaalDepartment of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-4694-6048
Pleun HombrinkSanquin Research and Landsteiner laboratory, Amsterdam, The Netherlands.
Benjamin NotaSanquin Research and Landsteiner laboratory, Amsterdam, The Netherlands.
Hanspeter PircherInstitute for Immunology, University Medical Centre Freiburg, Freiburg, Germany.ORCID 0000-0002-1777-9589
Ineke J M Ten BergeDepartment of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
René A W van LierSanquin Research and Landsteiner laboratory, Amsterdam, The Netherlands.
Michiel C van AalderenDepartment of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLSanquin · NLUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During acute viral infections in mice, IL-7Rα and KLRG1 together are used to distinguish the short-lived effector cells (SLEC; IL-7Rα

Indexed as

Gene ExpressionAdultCD8-Positive T-LymphocytesCytomegalovirusGene Expression ProfilingHerpes SimplexHLA AntigensHumansImmunocompromised HostImmunologic MemoryImmunophenotypingLectins, C-TypeLymph NodesLymphocyte ActivationMiddle AgedReceptors, ImmunologicHLA Antigensinterleukin-7 receptor, alpha chainKLRG1 protein, humanLectins, C-TypeReceptors, ImmunologicReceptors, Interleukin-7Human T-cell memoryIL-7 receptor-α-chainKiller cell lectin-like receptor subfamily G member 1Memory precursor effector cellsShort-lived effector cellsViral infection

Identifiers

PMID30883723
PMCPMC6593687
OpenAlexW2923371440

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.