ArticlePLoS biology2019
Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered resting-state brain function in diabetic retinopathy: a meta-analysis of combined transcriptome-neuroimaging study.Frontiers in endocrinology · 2026Pooled it
- Sex-Specific Neuropsychiatric Effects of Subanesthetic Ketamine Exposure in Pregnant Mice and Their Offspring.Cellular and molecular neurobiology · 2025Article
- Serotonin neuromodulation directs optic nerve regeneration.Development (Cambridge, England) · 2025Article
- Gut microbiome and host TOR pathway interact to regulate predator-induced aversive memory inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parental Serotonin Modulation Alters Monoamine Balance in Identified Neurons and Affects Locomotor Activity in Progeny ofInternational journal of molecular sciences · 2025Article
- Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach.Schizophrenia bulletin · 2024Article
- Expression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer.Frontiers in oncology · 2024Article
- Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice.Scientific reports · 2023Article
- Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice.Neural regeneration research · 2023Article
- Dietary energy restriction in neurological diseases: what's new?European journal of nutrition · 2023Review
- Zinc in Cognitive Impairment and Aging.Biomolecules · 2022Review
- Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings.Molecular psychiatry · 2022Review
- Janus-faced citrate in aging and metabolism.Aging · 2022Article
- G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation.Molecular pharmacology · 2022Review
- Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment.Frontiers in immunology · 2022Article
- Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.Aging cell · 2021Article
- Review
- Blockade of Serotonin 5-HTInternational journal of molecular sciences · 2021Article
- The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.Scientific reports · 2021Article
- Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders.Frontiers in psychiatry · 2021Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.