ReviewCurrent opinion in pulmonary medicine2019
Pleural effusion related to IgG4.
Review in Current opinion in pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Synchronous Extensive-Stage Small Cell Lung Cancer and Multiple Myeloma Detected by Marked Hypergammaglobulinemia.Cureus · 2026Article
- Clinicopathological Pearls and Diagnostic Pitfalls in IgG4-Related Disease: Challenging Case Series and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Eosinophilic Pleural Effusion as an Unusual Initial Manifestation of IgG4-Related Disease: A Diagnostic Challenge.Cureus · 2025Article
- IgG4-related disease and pleural effusion: a systematic review.Journal of thoracic disease · 2025Review
- IgG4 elevation dilemma at the crossroads of helminth infection and IgG4-related disease: insights from a case report of pediatric paragonimiasis with persistent pericardial effusion.Translational pediatrics · 2025Article
- Pleural Effusion: Shedding Light on Pleural Disease Beyond Infection and Malignancy.Medicina (Kaunas, Lithuania) · 2025Review
- IgG4 Related Disease Presenting With Eosinophilic Pleural Effusion.Respirology case reports · 2025Article
- A 69-year-old man with generalised lymphadenopathy, glandular swelling and pleural effusion.Breathe (Sheffield, England) · 2025Article
- IgG4-related pleural disease diagnosed by thoracoscopic pleural biopsy: A case report.Respirology case reports · 2024Article
- A case of massive hemoptysis caused by immunoglobulin G4-related respiratory disease in adults: case report and review of literature.Frontiers in immunology · 2024Review
- Navigating the Spectrum: Atypical Pulmonary Involvement in Immunoglobulin G4-Related Disease.Cureus · 2023Article
- IgG4-related eosinophilic pleural effusion: a case report.BMC geriatrics · 2023Article
- IgG4-related diseases involving pleura: a case report and literature review.Frontiers in medicine · 2023Article
- A case of immunoglobulin G4-Related disease with pleural effusion, requiring exclusion of tuberculous pleurisy.Respiratory medicine case reports · 2022Article
- Pleural Involvement in IgG4-Related Disease: Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2021Article
- Curious case of the unexplained exudative pleural effusion.BMJ case reports · 2021Article
- Asymptomatic pleural thickening with effusion as the only manifestation of IgG4-related disease.Respirology case reports · 2021Article
- Long-term clinical course and outcomes of immunoglobulin G4-related lung disease.Respiratory research · 2020Observational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe causes of exudative pleural effusions are diverse and frequently remain unclear despite exhaustive examinations. Recently recognized IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that can affect nearly any organ including the lungs. This review will focus on the involvement of IgG4 in exudative pleural effusion of unknown cause. RECENT
findingsIgG4 is found to be involved in a proportion of patients with undiagnosed pleural effusions. Pleural involvement in IgG4-RD can be seen in isolation or association with other organ disease. Pleural thickening and/or effusion are common clinical features of IgG4-related pleural lesions, and this condition is histologically characterized by a lymphoplasmacytic infiltrate enriched in IgG4-positive plasma cells in the pleura. Although the pathogenesis of IgG4-RD is poorly understood, there is a growing body of evidence that indicates an antigen-driven process requiring T-cell and B-cell interaction in which autoantibodies, plasmablasts, follicular helper T cells and CD4+ cytotoxic T lymphocytes participate. SUMMARY: The possibility of IgG4-related pleural lesion should be considered in patients with pleural effusion of unexplained cause when lymphoplasmacytic infiltration is seen in a pleural biopsy specimen. This condition is responsive to systemic steroid therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.