Evidence map›Paper›PMID 30883423›Full record

ReviewAnesthesia and analgesia2019

Neuroinflammation and Perioperative Neurocognitive Disorders.

Saraswathi Subramaniyan, Niccolò Terrando

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesia and analgesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07470216 (Cognitive Assessment And Post-Operative Complications After Surgery), which is not on this map. Cited by 246 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
246citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07470216 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk

TypeobservationalSponsorUniversity of EdinburghRan2026 to 2028Enrolled40ConditionsCognitive Impairment, Cognitive Impairment, Mild, Cognitive Impairment, Progressive, AnesthesiaArmsMontreal Cognitive Assessment, biomarkers
3 · Its place in the literature

Who cites it

246 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  20. A Neutrophil Membrane-Encapsulated Pd/hCeOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article

186 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Saraswathi SubramaniyanFrom the Center for Translational Pain Medicine, Department of Anesthe siology, Duke University Medical Center, Durham, North Carolina.
Niccolò Terrando

Funding

Neurovascular dysfunction in delirium superimposed on dementiaR01AG057525 · NIA · DUKE UNIVERSITY · PI Niccolo Terrando · 2017 to 2026
$6.7M
Bioelectronic rescue of cognitive impairment after surgeryR21AG055877 · NIA · DUKE UNIVERSITY · PI TERRANDO, NICCOLO · 2018 to 2019
$436k
NIA NIH HHS R01 AG057525NIA NIH HHS R21 AG055877
6 · The paper itself

Abstract

Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting postoperative cognitive dysfunction. Dysregulated inflammation and neuronal injury are emerging from clinical studies as key features of perioperative neurocognitive disorders. These findings are paralleled by a growing body of preclinical investigations aimed at better understanding how surgery and anesthesia affect the central nervous system and possibly contribute to cognitive decline. Herein, we review the role of postoperative neuroinflammation and underlying mechanisms in immune-to-brain signaling after peripheral surgery.

Indexed as

AnesthesiaAnesthesiologyAnimalsBiomarkersBlood-Brain BarrierBrainCognition DisordersCognitive DysfunctionDeliriumHumansInflammationNervous System DiseasesNeurocognitive DisordersNeuroimagingPerioperative PeriodPostoperative ComplicationsBiomarkers

Identifiers

PMID30883423
PMCPMC6437083

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.