Evidence map›Paper›PMID 30883356›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Ophthalmology-Based Neuropathology Risk Factors: Diabetic Retinopathy is Associated with Deep Microinfarcts in a Community-Based Autopsy Study.

Cecilia S Lee, Eric B Larson, Laura E Gibbons, Caitlin S Latimer, Shannon E Rose, Leanne L Hellstern, C Dirk Keene, Paul K Crane, Adult Changes in Thought (ACT) Study

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cecilia S LeeDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Laura E GibbonsDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Caitlin S LatimerDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Shannon E RoseDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Leanne L HellsternDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
C Dirk KeeneDepartment of Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Paul K CraneDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Adult Changes in Thought (ACT) Study
University of Washington · USKaiser Permanente Washington Health Research Institute · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI KEENE, CHRISTOPHER DIRK · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
The ocular surface microbiome in potentially infectious ophthalmic diseaseK23EY024921 · NEI · UNIVERSITY OF WASHINGTON · PI LEE, CECILIA SUNGMIN · 2015 to 2019
$991k
NEI NIH HHS K23 EY024921NIA NIH HHS P50 AG005136NIA NIH HHS U01 AG006781
6 · The paper itself

Abstract

backgroundThe aging eye offers unique opportunities to study and understand the aging brain, in particular related to Alzheimer's disease (AD) and dementia. However, little is known about relationships between eye diseases and dementia-related neurodegeneration.

objectiveTo determine the potential association between three age-related eye diseases and AD and dementia-related neuropathology.

methodsWe reviewed autopsy data from the prospective longitudinal Adult Changes in Thought (ACT) cohort. ICD-9 codes were used to identify diagnoses of diabetic retinopathy, glaucoma, and age-related macular degeneration. Multivariate regression models were used to determine odds ratios (OR) of neuropathology features associated with dementia, including Braak stage, Consortium to Establish a Registry for AD (CERAD score), Lewy bodies, hippocampal sclerosis, and microvascular brain injury, in addition to quantitative paired helical filament (PHF)-tau levels for people with and without each eye condition. We also evaluated interactions between eye conditions and dementia related neuropathologic findings were evaluated.

results676 autopsies were included. Diabetic retinopathy was significantly associated with increased risk of deep cerebral microinfarcts (OR = 1.91 [95% confidence interval (CI) 1.11, 3.27], p = 0.02). No other significant association or interaction between eye diseases and neuropathology was found. When PHF-tau quantity was evaluated in 124 decedents, the OR for the association between PHF-tau in the occipital cortex and glaucoma was 1.36 (95% CI 0.91, 2.03, p = 0.13). No statistical correction was made for multiple comparisons.

conclusionIncreased risk of deep cerebral microinfarcts was found in participants diagnosed with diabetic retinopathy. Eye diseases such as glaucoma may increase susceptibility to neurofibrillary tangles in the occipital cortex.

Indexed as

AgedAged, 80 and overAutopsyCerebral InfarctionCohort StudiesDementiaDiabetic RetinopathyFemaleHumansLongitudinal StudiesMaleMicrovesselsNeuropathologyOphthalmologyProspective StudiesRegistriesAlzheimer’s diseasediabetic retinopathyglaucomamacular degenerationneuropathology

Identifiers

PMID30883356
PMCPMC6450649
OpenAlexW2921622182

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.