Evidence map›Paper›PMID 30883349›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Background Risk Factors Associated with Shunt Intervention for Possible Idiopathic Normal Pressure Hydrocephalus: A Nationwide Hospital-Based Survey in Japan.

Madoka Nakajima, Nagato Kuriyama, Masakazu Miyajima, Ikuko Ogino, Chihiro Akiba, Kaito Kawamura, Michiko Kurosawa, Yoshiyuki Watanabe, Wakaba Fukushima, Etsuro Mori and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Madoka NakajimaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Nagato KuriyamaDepartment of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masakazu MiyajimaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Ikuko OginoDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Chihiro AkibaDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Kaito KawamuraDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Michiko KurosawaDepartment of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, Tokyo, Japan.
Yoshiyuki WatanabeDepartment of Public Administrative Science for Community Health, Medicine and Welfare, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
Wakaba FukushimaDepartment of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan.
Etsuro MoriDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
Takeo KatoDepartment of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Hidenori SuganoDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Yuichi TangeDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Kostadin KaragiozovDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Hajime AraiDepartment of Neurosurgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Juntendo University · JPKyoto Prefectural University of Medicine · JPOsaka City University · JPThe University of Osaka · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with idiopathic normal-pressure hydrocephalus (iNPH) are typically older adults with multiple comorbidities that are associated with a reduction in the efficacy of iNPH treatment via cerebrospinal fluid (CSF) shunt placement.

objectiveThe present study aimed to investigate the effectiveness of CSF shunt for iNPH using data from a nationwide epidemiological survey in Japan.

methodsWe examined 1,423 patients (581 women) aged ≥60 years (median age [25%-75%]: 77 [73-80] years) who were diagnosed with iNPH following a hospital visit in 2012. Patients who experienced an improvement of at least one modified Rankin Scale (mRS) grade after the CSF shunt were classified as "improvement" while the remaining patients were classified as "non-improvement." The efficacy of the shunt intervention (n = 842) was analyzed using a binomial logistic regression analysis.

resultsAn analysis of risk factors associated with shunt placement in patients with mRS grade 2 revealed an association between comorbid chronic ischemic lesions (odds ratio [OR], 2.28; 95% confidence interval [CI], 1.11-4.67; p = 0.025) and cervical spondylosis (OR, 3.62; 95% CI, 1.15-11.34; p = 0.027). Patients with mRS grade 3 at study entry had an association with comorbid Alzheimer's disease (OR, 3.02; 95% CI, 1.44-6.31; p = 0.003).

conclusionsThe results presented here showed that any age-related risk is minimal and should not be cause for rejection of surgical treatment options. Clinical decisions regarding CSF shunt should be individualized to each patient, with adequate consideration of the relative risks and benefits, including maximizing a healthy life expectancy.

Indexed as

Surveys and QuestionnairesAgedAged, 80 and overAlzheimer DiseaseCerebrospinal Fluid ShuntsFemaleFollow-Up StudiesHospitalizationHospitalsHumansHydrocephalus, Normal PressureJapanMaleMiddle AgedRisk FactorsAlzheimer’s diseasecerebrospinal fluid shuntgeriatric carehealthy life expectancynormal pressure hydrocephalus

Identifiers

PMID30883349
PMCPMC6484254
OpenAlexW2922172796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.