Evidence map›Paper›PMID 30883044›Full record

ArticleInternational wound journal2019

Surfactants: Role in biofilm management and cellular behaviour.

Steven L Percival, Dieter Mayer, Robert S Kirsner, Greg Schultz, Dot Weir, Sashwati Roy, Afsaneh Alavi, Marco Romanelli

Open access · bronzeAbstract read
In one paragraph

Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. An IntactJournal of ophthalmology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. What's New in Wound Healing: Treatment Advances and Microbial Insights.American journal of clinical dermatology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 5 countries.

Steven L Percival5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, Liverpool, UK.
Dieter MayerDepartment of Surgery, HFR Fribourg - Cantonal Hospital, Fribourg, Switzerland.
Robert S KirsnerDr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida.
Greg SchultzInstitute for Wound Research, University of Florida, Gainesville, Florida.
Dot WeirCatholic Health Advanced Wound Healing Centers, Buffalo, New York.
Sashwati RoyDepartment of Surgery, Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, Indiana.
Afsaneh AlaviDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Marco RomanelliDepartment of Dermatology, University of Pisa, Pisa, Italy.
Fribourg Development Agency · CHIndiana University School of MedicineUniversity of Florida · USUniversity of Liverpool · GBUniversity of Miami · USUniversity of Pisa · ITUniversity of Toronto · CAWound Healing Society · US

Funding

Medline Industries Inc
6 · The paper itself

Abstract

Appropriate and effective wound cleaning represents an important process that is necessary for preparing the wound for improved wound healing and for helping to dislodge biofilms. Wound cleaning is of paramount importance to wound bed preparation for helping to enhance wound healing. Surfactant applications in wound care may represent an important area in the cleaning continuum. However, understanding of the role and significance of surfactants in wound cleansing, biofilm prevention and control, and enhancing cellular viability and proliferation is currently lacking. Despite this, some recent evidence on poloxamer-based surfactants where the surfactants are present in high concentration have been shown to have an important role to play in biofilm management; matrix metalloproteinase modulation; reducing inflammation; and enhancing cellular proliferation, behaviour, and viability. Consequently, this review aims to discuss the role, mode of action, and clinical significance of the use of medically accepted surfactants, with a focus on concentrated poloxamer-based surfactants, to wound healing but, more specifically, the role they may play in biofilm management and effects on cellular repair.

Indexed as

BiofilmsCell EnlargementCell ProliferationDisinfectantsHumansSurface-Active AgentsWound HealingWound InfectionDisinfectantsSurface-Active Agentsbiofilmscell salvagechronic woundssurfactants

Identifiers

PMID30883044
PMCPMC7948769
OpenAlexW2921438307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.