Evidence map›Paper›PMID 30882927›Full record

Trial reportTransfusion2019

Influence of blood storage age on immune and coagulation parameters in critically ill transfused patients.

Philip J Norris, Ken Schechtman, Heather C Inglis, Avril Adelman, John W Heitman, Ryan Vilardi, Avani Shah, Nareg H Roubinian, Ali Danesh, Anne M Guiltinan and 4 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Observational
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Philip J NorrisVitalant Research Institute, University of California, San Francisco, California.
Ken SchechtmanDepartment of Biostatistics, Washington University School of Medicine, St. Louis, Missouri.
Heather C InglisVitalant Research Institute, University of California, San Francisco, California.
Avril AdelmanDepartment of Biostatistics, Washington University School of Medicine, St. Louis, Missouri.
John W HeitmanVitalant Research Institute, University of California, San Francisco, California.
Ryan VilardiDepartment of Surgery, University of California, San Francisco, California.
Avani ShahVitalant Research Institute, University of California, San Francisco, California.
Nareg H RoubinianVitalant Research Institute, University of California, San Francisco, California.
Ali DaneshVitalant Research Institute, University of California, San Francisco, California.
Anne M GuiltinanVitalant Research Institute, University of California, San Francisco, California.
Sheila M KeatingVitalant Research Institute, University of California, San Francisco, California.
Jacques LacroixCentre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montréal, Montreal, Canada.
Mitchell J CohenDepartment of Surgery, University of California, San Francisco, California.
Philip C SpinellaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
University of California, San Francisco · USVitalant · USWashington University in St. Louis · USPacific Research Institute · USUniversité de Montréal · CA

Funding

Properties of stored RBCs: minimization of immune and vascular reactivityR01HL095470 · NHLBI · VITALANT · PI NORRIS, PHILIP J. · 2009 to 2012
$2.3M
NHLBI NIH HHS R01 HL095470
6 · The paper itself

Abstract

backgroundSeveral retrospective studies have suggested that transfusion with red blood cells (RBCs) stored for longer periods is associated with increased mortality. The Age of Blood Evaluation (ABLE) study randomized subjects to receive fresh vs. standard issue RBC units and showed no difference in the primary or secondary endpoints of mortality or change in multi-organ dysfunction syndrome (MODS) score.

methodsIn this study a subset of 100 ABLE subjects were enrolled to measure coagulation and immune parameters. Samples were collected pre-transfusion and on days 2, 6, 28, and 180 post-transfusion. Levels of 16 coagulation parameters, regulatory and functional T cells, 25 cytokines, and 16 markers of extracellular vesicles (EVs) were determined.

resultsChanges from baseline in levels of protein C, factor V, and EVs expressing phosphatidyl serine and CTLA-4 (CD152) differed between recipients of fresh and standard storage age RBC units, with the vast majority of coagulation and EV markers and all cytokines tested showing no difference between study arms. Although most analytes showed no difference between subjects in the fresh and standard arms of the study, 6 coagulation parameters, 15 cytokines, and 7 EV parameters changed significantly in the period post-transfusion. DISCUSSION: Transfusion of fresh vs. standard issue RBC units does not result in substantial changes in coagulation or immune parameters, up to day 35 of RBC storage. Furthermore, significant changes in multiple coagulation and immune parameters are detectable post-transfusion, though causality cannot be determined based on the current study.

Indexed as

Blood CoagulationBlood PreservationCytokinesErythrocytesErythrocyte TransfusionExtracellular VesiclesBiomarkersCritical IllnessFemaleHumansMaleMiddle AgedTime FactorsBiomarkersCytokines

Identifiers

PMID30882927
PMCPMC6450744
OpenAlexW2921529700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.