Evidence map›Paper›PMID 30882910›Full record

Observational studyJournal of the American Geriatrics Society2019

Healthcare and Financial Decision Making and Incident Adverse Cognitive Outcomes among Older Adults.

Christopher C Stewart, Lei Yu, Robert S Wilson, David A Bennett, Patricia A Boyle

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Change in Decision-Making Analysis and Preferences in Old Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  6. Article
  7. Article
  8. Purpose in Life and Cognition Interact to Impact Healthcare and Financial Decision Making in Old Age.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022
    Article
  9. Article
  10. Article
  11. The "cognitive clock": A novel indicator of brain health.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher C StewartDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Robert S WilsonRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Patricia A BoyleRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Epidemiologic Study of Impaired Decision-Making in Preclinical Alzheimer's DiseasR01AG033678 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2009 to 2025
$7.8M
Epidemiology of racial differences in decision making among older adultsR01AG060376 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2018 to 2022
$3.2M
National Institute on Aging (NIA) R01AG017917National Institute on Aging (NIA) R01AG033678National Institute on Aging (NIA) R01AG034374National Institute on Aging (NIA) R01AG060376NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374NIA NIH HHS R01 AG060376
6 · The paper itself

Abstract

objectivesTo determine if poorer healthcare and financial decision making forecasts adverse cognitive outcomes in old age. Specifically, we hypothesized that poorer decision making would be associated with an increased risk of incident Alzheimer's dementia, an increased risk of incident mild cognitive impairment (MCI), and a more rapid decline in cognition.

designAn ongoing prospective observational cohort study of aging (the Rush Memory and Aging Project).

settingThe greater Chicago area.

participantsA total of 952 community-based older adults without dementia at baseline. MEASUREMENTS: Participants completed a measure of healthcare and financial decision making at baseline and underwent annual standardized evaluations to track clinical status and cognitive functions (global cognition, episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability).

resultsDuring up to 9 years of follow-up (M = 5.2 y; standard deviation = 2.7), 156 participants developed Alzheimer's dementia (16.4% of 952), 253 participants developed MCI (33.2% of 760), and each cognitive measure declined (all Ps < .001). In Cox proportional hazards models adjusted for age, sex, and education, poorer decision making was associated with an increased risk of incident Alzheimer's dementia (hazard ratio [HR] = 1.17; 95% confidence interval [CI] = 1.10-1.24; P < .001) and incident MCI (HR = 1.16; 95% CI = 1.10-1.22; P < .001). Further, in linear mixed-effects models, poorer decision making among those who were initially free of cognitive impairment was associated with a more rapid decline in global cognition and four of five specific cognitive domains (all Ps < .05).

conclusionOur results suggest that poorer healthcare and financial decision making heralds adverse cognitive outcomes in old age. J Am Geriatr Soc 67:1590-1595, 2019.

Indexed as

CognitionDecision MakingAgedAged, 80 and overAlzheimer DiseaseChicagoCognitive DysfunctionFemaleFinancing, PersonalHumansIncidenceMalePatient Acceptance of Health CareProportional Hazards ModelsProspective StudiesagingAlzheimer's dementiacognitiondecision makingmild cognitive impairment

Identifiers

PMID30882910
PMCPMC9801701

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.