ArticleJournal of the American Geriatrics Society2019
Delirium Incidence and Functional Outcomes After Transcatheter and Surgical Aortic Valve Replacement.
Article in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01845207 (Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term clinical outcomes of delirium after hospital discharge: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- Intraoperative suggestions to prevent postoperative delirium in patients undergoing transaortic valvular replacement: a randomized placebo-controlled trial.Aging clinical and experimental research · 2023Trial
- Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery.Bioscience reports · 2020Trial
- Delirium Among Adults Undergoing Transcatheter Structural Heart Intervention: Incidence, Risk, and Clinical Phenotypes.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Transcranial doppler assessment of preoperative cerebral blood flow velocity in cardiac surgery patients.Journal of clinical monitoring and computing · 2026Observational
- Regional Cerebral Blood Flow Increase After Transcatheter Aortic Valve Replacement Is Related to Cardiac Output but Is Not Associated with Delirium: An Observational Cohort Study Using Transcranial Indocyanine Green Dye Dilution Technique.Journal of clinical medicine · 2025Article
- Postoperative delirium in patients undergoing TAVI versus SAVR - A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2024Article
- Postoperative delirium in 47 379 individuals undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Review
- Effects of inflammation and oxidative stress on postoperative delirium in cardiac surgery.Frontiers in cardiovascular medicine · 2022Review
- Delirium in older patients undergoing aortic valve replacement: incidence, predictors, and cognitive prognosis.BMC geriatrics · 2021Article
- Evolution of Basic Activities of Daily Living Function in Older Patients One Year After Transcatheter Aortic Valve Implantation.Journal of the American Geriatrics Society · 2021Article
- Predisposing and Precipitating Risk Factors for Delirium in Elderly Patients Admitted to a Cardiology Ward: An Observational Cohort Study in 1,042 Patients.Frontiers in cardiovascular medicine · 2021Article
- Incidence, Risk Factors and Impact on Long-Term Outcome of Postoperative Delirium After Transcatheter Aortic Valve Replacement.Frontiers in cardiovascular medicine · 2021Article
- Delirium, functional decline and quality of life after transcatheter aortic valve implantation: An explorative study.Geriatrics & gerontology international · 2020Article
- Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study.Geriatrics (Basel, Switzerland) · 2020Article
- Cognition, Frailty, and Functional Outcomes of Transcatheter Aortic Valve Replacement.The American journal of medicine · 2020Article
- Physical Performance and Risk of Postoperative Delirium in Older Adults Undergoing Aortic Valve Replacement.Clinical interventions in aging · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundTranscatheter aortic valve replacement (TAVR) may be associated with less delirium and allow faster recovery than surgical aortic valve replacement (SAVR).
objectiveTo examine the association of delirium and its severity with clinical and functional outcomes after SAVR and TAVR.
designProspective cohort study.
settingAn academic medical center.
participantsA total of 187 patients, aged 70 years and older, undergoing SAVR (N = 77) and TAVR (N = 110) in 2014 to 2016. MEASUREMENTS: Delirium was assessed daily using the Confusion Assessment Method (CAM), with severity measured by the CAM-Severity (CAM-S) score (range = 0-19). Outcomes were prolonged hospitalization (9 days or more); institutional discharge; and functional status, measured by ability to perform 22 daily activities and physical tasks over 12 months.
resultsSAVR patients had a higher incidence of delirium than TAVR patients (50.7% vs 25.5%; P < .001), despite younger mean age (77.9 vs 83.7 years) and higher baseline Mini-Mental State Examination score (26.9 vs 24.7). SAVR patients with delirium had a shorter duration (2.2 vs 3.4 days; P = .04) with a lower mean CAM-S score (4.5 vs 5.7; P = .01) than TAVR patients with delirium. The risk of prolonged hospitalization in no, mild, and severe delirium was 18.4%, 30.8%, and 61.5% after SAVR (P for trend = .009) and 26.8%, 38.5%, and 73.3% after TAVR (P for trend = .001), respectively. The risk of institutional discharge was 42.1%, 58.3%, and 84.6% after SAVR (P for trend = .01) and 32.5%, 69.2%, and 80.0% after TAVR (P for trend <.001), respectively. Severe delirium was associated with delayed functional recovery after SAVR and persistent functional impairment after TAVR at 12 months.
conclusionLess invasive TAVR was associated with lower incidence of delirium than SAVR. Once delirium developed, TAVR patients had more severe delirium and worse functional status trajectory than SAVR patients did. REGISTRATION: NCT01845207.
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