Evidence map›Paper›PMID 30882733›Full record

ArticleThe Pediatric infectious disease journal2019

Decreased Prevalence of Rheumatic Heart Disease Confirmed Among HIV-positive Youth.

Ian W Hovis, Judith Namuyonga, Grace P Kisitu, Emma Ndagire, Emmy Okello, Chris T Longenecker, Amy Sanyahumbi, Craig A Sable, Daniel J Penny, Peter Lwabi and 2 more

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In one paragraph

Article in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Ian W HovisFrom the Children's National Health System, Washington, District of Columbia.
Judith NamuyongaUganda Heart Institute.
Grace P KisituBaylor College of Medicine Children's Foundation, Mulago Hospital, Kampala, Uganda.
Emma NdagireUganda Heart Institute.
Emmy OkelloUganda Heart Institute.
Chris T LongeneckerCase Western Reserve University School of Medicine, Cleveland, Ohio.
Amy SanyahumbiBaylor College of Medicine, Texas Children's Hospital, Houston, Texas.
Craig A SableFrom the Children's National Health System, Washington, District of Columbia.
Daniel J PennyBaylor College of Medicine, Texas Children's Hospital, Houston, Texas.
Peter LwabiUganda Heart Institute.
Adeodata R KekitiinwaBaylor College of Medicine Children's Foundation, Mulago Hospital, Kampala, Uganda.
Andrea BeatonFrom the Children's National Health System, Washington, District of Columbia.
Uganda Management Institute · UGChildren's National · USMulago Hospital · UGBaylor College of Medicine · USTexas Children's Hospital · USUniversity School · US

Funding

Pericardial fat, inflammation, and structural heart disease in HIVK23HL123341 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LONGENECKER, CHRIS TODD · 2014 to 2018
$885k
NHLBI NIH HHS K23 HL123341
6 · The paper itself

Abstract

backgroundThere is geographical overlap between areas endemic for rheumatic heart disease (RHD) and those endemic for HIV. A recent pilot study demonstrated that children living with HIV might be at less risk for RHD development; however, the sample size was too small to make definitive conclusions. Our objective was to determine the prevalence of RHD among HIV-positive children in Uganda.

methodsWe conducted a prospective, cross-sectional study of HIV-positive children (5-15 years of age) receiving care at the Baylor Uganda HIV Clinic, Kampala, Uganda. A focused echocardiogram and chart review was performed. A sample size of 988 children was needed to provide 80% power to detect a difference in population prevalence between HIV-positive children and the general population, 2.97% [95% confidence interval (CI): 2.70-3.24%], based on previous reports.

resultsScreening echocardiography of 993 HIV-positive children found 15 individuals (1.5%; 95% CI: 0.88%-2.54%) with RHD. Of these 15, 2 were classified as definite RHD and 13 as borderline RHD. The majority of children had isolated mitral valve disease (93%). Children found to have RHD were older than those without RHD, 12 versus 10 years of age (P = 0.004). When separated based on geographic location, the prevalence of RHD among HIV-positive children from Kampala was 1.28% (95% CI: 0.63%-2.51%) compared with 2.1% (95% CI: 0.89%-4.89%) in those from outside Kampala.

conclusionsChildren living with HIV have a lower prevalence of RHD than the general pediatric population. Further studies are needed to explore this protective association.

Indexed as

AdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHIV InfectionsHumansMalePrevalenceProspective StudiesRheumatic Heart DiseaseRisk AssessmentUganda

Identifiers

PMID30882733
PMCPMC6355385
OpenAlexW2885104139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.