Evidence map›Paper›PMID 30882596›Full record

ArticleJournal of hypertension2019

Blood pressure, antihypertensive medication use, and risk of erectile dysfunction in men with type I diabetes.

Aruna V Sarma, James M Hotaling, Ian H de Boer, Rodney L Dunn, Mary K Oerline, Karandeep Singh, Jack Goldberg, Alan Jacobson, Barbara Braffett, William H Herman and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Correlations of the Circadian Rhythmicity of Blood Pressure With Erectile Dysfunction.Journal of clinical hypertension (Greenwich, Conn.) · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Aruna V SarmaDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
James M HotalingDepartment of Urology, University of Utah, Salt Lake City, Utah.
Ian H de BoerDepartment of Medicine, University of Washington, Seattle, Washington.
Rodney L DunnDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Mary K OerlineDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Karandeep SinghDepartment of Learning Health Sciences, University of Michigan, Ann Arbor, Michigan.
Jack GoldbergDepartment of Epidemiology, University of Washington, Seattle, Washington.
Alan JacobsonResearch Institute, NYU Winthrop University Hospital, Mineola, New York.
Barbara BraffettBiostatistics Center, George Washington University, Rockville, Maryland.
William H HermanDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Rodica Pop-BusuiDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Hunter WessellsDepartment of Urology and Diabetes Research Center, University of Washington, Seattle, Washington, USA.
DCCT/EDIC Research Group
University of Michigan–Ann Arbor · USUniversity of Washington · USGeorge Washington University · USUniversity of Utah · USWinthrop-University Hospital · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- DiabetesR01DK083927 · NIDDK · UNIVERSITY OF WASHINGTON · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2009 to 2013
$2.7M
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK083927NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

objectiveTo gain insight into the effect of blood pressure on the pathophysiology of diabetic erectile dysfunction, we determined the onset, severity and treatment of hypertension and risk of incident erectile dysfunction in men with type I diabetes.

methodsThis prospective cohort study included 692 men without prevalent erectile dysfunction in the Epidemiology of Diabetes Interventions and Complications study. Erectile dysfunction was assessed yearly for 16 years with a single question querying presence of impotence. Multivariable cox proportional hazards models examined associations of hypertension variables with risk for incident erectile dysfunction.

resultsOver 7762 person-years of follow-up, 337 of 692 men reported incident erectile dysfunction representing an unadjusted rate of 43.4 cases per 1000 person-years. Risk of erectile dysfunction significantly increased with each 10 mmHg of SBP elevation for those not taking antihypertensive medications, after adjustment for age, cigarette smoking and HbA1c levels [relative risk (RR) = 1.21, 95% CI = 1.04-1.41]. This relationship disappeared among those reporting antihypertensive medication use (RR = 0.96, 95% CI = 0.84-1.10) and the interaction between SBP and medication use was statistically significant (P = 0.02). Antihypertensive medication did not confer any reduction of erectile dysfunction risk, with similar rates across all measures of blood pressure and hypertension.

conclusionAmong men with type 1 diabetes not using antihypertensive medications, higher SBP is associated with increased risk of developing erectile dysfunction. These findings provide evidence to support further investigation into the potential benefit of early blood pressure control on risk of erectile dysfunction in men with diabetes regardless of age, blood pressure level, or glycemic control.

Indexed as

Blood PressureAdultAntihypertensive AgentsDiabetes Mellitus, Type 1Erectile DysfunctionFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsYoung AdultAntihypertensive Agents

Identifiers

PMID30882596
PMCPMC7223638
OpenAlexW2923359754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.