Evidence map›Paper›PMID 30882493›Full record

ArticleAIDS (London, England)2019

Point-of-care HIV RNA testing and immediate antiretroviral therapy initiation in young adults seeking out-patient care in Kenya.

Eduard J Sanders, Oscar Chirro, Clifford Oduor, Juma Mangi, Elizabeth Wahome, Matthew A Price, Hubert C Gelderblom, Elisabeth M van der Elst, Susan M Graham

Abstract read
In one paragraph

Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Symptom-based Scoring for Acute Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eduard J SandersKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Oscar ChirroKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Clifford OduorKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Juma MangiMalindi Sub-County Hospital, Malindi, Kenya.
Elizabeth WahomeKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Matthew A PriceInternational AIDS Vaccine Initiative, New York, New York, USA.
Hubert C GelderblomKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Elisabeth M van der ElstKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Susan M GrahamKenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.

Funding

Impact of a novel screening program to detect acute and prevalent HIV infection and reduce HIV transmissionR01AI124968 · NIAID · UNIVERSITY OF WASHINGTON · PI GRAHAM, SUSAN MARIE, SANDERS, EDUARD · 2016 to 2019
$2.3M
NIAID NIH HHS R01 AI124968Wellcome Trust 203077/Z/16/Z
6 · The paper itself

Abstract

: We evaluated outcomes of an HIV-1-testing intervention using rapid HIV tests followed by point-of-care Xpert Qual testing for HIV-1 RNA. Of 706 young urgent-care seeking participants evaluated, 24 (3.4%) had chronic HIV (antibody-positive), 3 (0.4%) acute HIV-1 (Qual-positive, antibody-negative), and 3 (0.4%) early HIV-1 infection (Qual-positive, antibody-discordant). Overall, 21 (70.0%) diagnosed patients started antiretroviral therapy after a median of 4 days (range 0-71). HIV-1 RNA testing led to an increase in confirmed diagnoses by 25%.

Indexed as

Point-of-Care TestingAdultDiagnostic Tests, RoutineFemaleHealth Care SurveysHIV InfectionsHumansKenyaMaleMass ScreeningOutpatientsRNA, ViralYoung AdultRNA, Viral

Identifiers

PMID30882493
PMCPMC6426340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.