Evidence map›Paper›PMID 30882491›Full record

SynthesisAIDS (London, England)2019

Integration of care for HIV and opioid use disorder.

Benjamin J Oldfield, Nicolas Muñoz, Mark P McGovern, Melissa Funaro, Merceditas Villanueva, Jeanette M Tetrault, E Jennifer Edelman

2 registry-linked trialsOpen access · greenAbstract readSystematic Review
In one paragraph

Synthesis in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04601064 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2026Enrolled405ConditionsHIV Infections, Substance Use Disorders, Mental Health Disorder, AddictionArmsCollaborative Care Model
NCT07115030 narecruitingnot on this mapstarted 2026, after this paper: background citation

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

TypeinterventionalSponsorYale UniversityRan2026 to 2029Enrolled532ConditionsOpioid Use Disorder, Intimate Partner Violence (IPV), Post Traumatic Stress Disorder PTSDArmsPCT+2HOPE
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benjamin J OldfieldNational Clinician Scholars Program.
Nicolas MuñozDepartment of Medicine.
Mark P McGovernDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
Melissa FunaroHarvey Cushing/John Hay Whitney Medical Library, Yale University.
Merceditas VillanuevaDepartment of Medicine.
Jeanette M TetraultDepartment of Medicine.
E Jennifer EdelmanDepartment of Medicine.
Yale University · USStanford University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Working with HIV clinics to adopt addiction treatments using Implementation Facilitation (WHAT IF?)R01DA041067 · NIDA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2015 to 2019
$2.9M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA041067
6 · The paper itself

Abstract

objectiveWe sought to identify optimal strategies for integrating HIV- and opioid use disorder-(OUD) screening and treatment in diverse settings.

designSystematic review.

methodsWe searched Ovid MEDLINE, PubMed, Embase, PsycINFO and preidentified websites. Studies were included if they were published in English on or after 2002 through May 2017, and evaluated interventions that integrated, at an organizational level, screening and/or treatment for HIV and OUD in any care setting in any country.

resultsTwenty-nine articles met criteria for inclusion, including 23 unique studies: six took place in HIV care settings, 12 in opioid treatment settings, and five elsewhere. Eight involved screening strategies, 22 involved treatment strategies, and seven involved strategies that encompassed screening and treatment. Randomized controlled studies demonstrated low-to-moderate risk of bias and observational studies demonstrated fair to good quality. Studies in HIV care settings (n = 6) identified HIV-related and OUD-related clinical benefits with the use of buprenorphine/naloxone for OUD. No studies in HIV care settings focused on screening for OUD. Studies in opioid treatment settings (n = 12) identified improving HIV screening uptake and clinical benefits with antiretroviral therapy when provided on-site. Counseling intensity for OUD medication adherence or HIV-related risk reduction was not associated with clinical benefits.

conclusionScreening for HIV can be effectively delivered in opioid treatment settings, yet there is a need to identify optimal OUD screening strategies in HIV care settings. Strategies integrating the provision of medications for HIV and for OUD should be expanded and should not be contingent on resources available for behavioral interventions. REGISTRATION: A protocol for record eligibility was developed a priori and was registered in the PROSPERO database of systematic reviews (registration number CRD42017069314).

Indexed as

Analgesics, OpioidBehavior TherapyDirective CounselingHIV InfectionsHumansMedication AdherenceOpiate Substitution TreatmentOpioid-Related DisordersRandomized Controlled Trials as TopicTreatment OutcomeAnalgesics, Opioid

Identifiers

PMID30882491
PMCPMC6588508
OpenAlexW2906139775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.