Evidence map›Paper›PMID 30882477›Full record

Trial reportCritical care medicine2019

High-Flow Oxygen Therapy After Noninvasive Ventilation Interruption in Patients Recovering From Hypercapnic Acute Respiratory Failure: A Physiological Crossover Trial.

Federico Longhini, Lara Pisani, Ramona Lungu, Vittoria Comellini, Andrea Bruni, Eugenio Garofalo, Maria Laura Vega, Gianmaria Cammarota, Stefano Nava, Paolo Navalesi

3 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04016480 nacompletednot on this map

High Flow Oxygen Therapy Through Nasal Cannula in Patients With Acute Respiratory Failure During Bronchoscopy for Bronchoalveolar Lavage

TypeinterventionalSponsorUniversity Magna GraeciaRan2019 to 2020Enrolled36ConditionsAcute Respiratory Failure, Bronchoscopy, Bronchoalveolar LavageArmsHigh Flow Nasal Cannula, Conventional Oxygen Therapy
NCT06204276 nacompletednot on this mapstarted 2024, after this paper: background citation

The Physiologic Effects of Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure. A Randomized Crossover Study.

TypeinterventionalSponsorSiriraj HospitalRan2024 to 2024Enrolled40ConditionsAcute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory FailureArmsExperimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula
NCT07133698 nacompletednot on this mapstarted 2024, after this paper: background citation

High Flow Nasal Cannula vs. High Velocity Nasal Insufflation for Weaning From Mechanical Ventilation in Respiratory ICU

TypeinterventionalSponsorAssiut UniversityRan2024 to 2025Enrolled105ConditionsWeaning From Mechanical VentilationArmsHigh Flow nasal Cannula, High velocity nasal insufflation, Noninvasive ventilation
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Federico LonghiniAnesthesia and Intensive Care, Sant'Andrea Hospital, ASL VC, Vercelli, Italy.
Lara PisaniDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Ramona LunguAnesthesia and Intensive Care, Maggiore della Carità Hospital, Novara, Italy.
Vittoria ComelliniDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Andrea BruniIntensive Care Unit, University Hospital Mater Domini, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Eugenio GarofaloIntensive Care Unit, University Hospital Mater Domini, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Maria Laura VegaDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Gianmaria CammarotaAnesthesia and Intensive Care, Maggiore della Carità Hospital, Novara, Italy.
Stefano NavaDepartment of Clinical, Integrated and Experimental Medicine (DIMES), Respiratory and Critical Care Unit, S. Orsola-Malpighi Hospital, Alma Mater University, Bologna, Italy.
Paolo NavalesiIntensive Care Unit, University Hospital Mater Domini, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Policlinico S.Orsola-Malpighi · ITAzienda Ospedaliero Universitario Mater Domini · ITCTO Andrea Alesini · ITMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAssessing gas exchange, diaphragm function, respiratory rate, and patient comfort during high-flow oxygen therapy and standard oxygen at the time of noninvasive ventilation discontinuation.

designRandomized crossover physiologic study.

settingTwo ICUs. PATIENTS: Thirty chronic obstructive pulmonary disease patients with hypercapnic acute respiratory failure receiving noninvasive ventilation greater than 24 hours.

interventionsAll patients underwent five 30-minute trials, the first, third, and fifth trial in noninvasive ventilation, whereas the second and fourth were randomly conducted with either standard oxygen and high-flow oxygen therapy. MEASUREMENTS AND MAIN

resultsDiaphragm displacement and thickening fraction were determined by sonographic evaluation at the end of each trial. Arterial blood gases, respiratory rate, and patient comfort were also assessed. PaCO2 (p = 0.153) and pH (p = 0.114) were not different among trials, while PaO2 was greater in noninvasive ventilation than with both standard oxygen (p ≤ 0.005) and high-flow oxygen therapy (p ≤ 0.001). The diaphragm displacement was no different among trials (p = 0.875), while its thickening fraction was greater with standard oxygen, compared with high-flow oxygen therapy and all noninvasive ventilation trials (p < 0.001 for all comparisons), without differences between high-flow oxygen therapy and noninvasive ventilation. Respiratory rate also increased with standard oxygen, compared with both high-flow oxygen therapy (p < 0.001) and noninvasive ventilation (p < 0.01). High-flow oxygen therapy improved comfort, compared with standard oxygen (p = 0.004) and noninvasive ventilation (p < 0.001).

conclusionsAt the time of noninvasive ventilation interruption, PaCO2 and diaphragm displacement remained unchanged regardless of the modality of oxygen administration. However, although standard oxygen resulted in a remarkable increase in diaphragm thickening fraction, high-flow oxygen therapy allowed maintaining it unchanged, while improving patient comfort.

Indexed as

AgedAged, 80 and overBlood Gas AnalysisCarbon DioxideCross-Over StudiesDiaphragmFemaleHumansHypercapniaMaleMiddle AgedNoninvasive VentilationOxygenOxygen Inhalation TherapyPartial PressurePatient ComfortCarbon DioxideOxygen

Identifiers

PMID30882477
OpenAlexW2924109498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.