ArticleeLife2019
Behavioural and neural signatures of perceptual decision-making are modulated by pupil-linked arousal.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pupil Reactions to Tactile Stimulation: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Transcutaneous vagus nerve stimulation boosts evidence accumulation during perceptual decision making.iScience · 2026Article
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- The Contribution of the Locus Ceruleus-Norepinephrine System to the Coupling between Pupil-Linked Arousal and Cortical State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Pupillary dynamics during hands-off L2 driving and transitions of control under high cognitive load.PloS one · 2026Article
- Pupil size predicts exploration through critical slowing in prefrontal dynamics.Communications biology · 2025Article
- When your heart isn't in it anymore: cardiac correlates of task disengagement.Communications biology · 2025Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
- Pupil size predicts the onset of exploration and changes in prefrontal dynamics.bioRxiv : the preprint server for biology · 2025Article
- Sleuthing subjectivity: a review of covert measures of consciousness.Nature reviews. Neuroscience · 2025Review
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.bioRxiv : the preprint server for biology · 2025Article
- Target Selection Signals Causally Influence Human Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Expectation violations signal goals in novel human communication.Nature communications · 2025Article
- Article
- Spontaneous slow cortical potentials and brain oscillations independently influence conscious visual perception.PLoS biology · 2025Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The timing and accuracy of perceptual decision-making is exquisitely sensitive to fluctuations in arousal. Although extensive research has highlighted the role of various neural processing stages in forming decisions, our understanding of how arousal impacts these processes remains limited. Here we isolated electrophysiological signatures of decision-making alongside signals reflecting target selection, attentional engagement and motor output and examined their modulation as a function of tonic and phasic arousal, indexed by baseline and task-evoked pupil diameter, respectively. Reaction times were shorter on trials with lower tonic, and higher phasic arousal. Additionally, these two pupil measures were predictive of a unique set of EEG signatures that together represent multiple information processing steps of decision-making. Finally, behavioural variability associated with fluctuations in tonic and phasic arousal, indicative of neuromodulators acting on multiple timescales, was mediated by its effects on the EEG markers of attentional engagement, sensory processing and the variability in decision processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.