Evidence map›Paper›PMID 30882333›Full record

ArticleEmerging infectious diseases2019

Klebsiella pneumoniae ST307 with bla

Michelle Lowe, Marleen M Kock, Jennifer Coetzee, Ebrahim Hoosien, Gisele Peirano, Kathy-Ann Strydom, Marthie M Ehlers, Nontombi M Mbelle, Elena Shashkina, David B Haslam and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pathogens (Basel, Switzerland) · 2024
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Epidemiological Insights into Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Rapidly spreadingJournal of clinical microbiology · 2025
    Review
  16. Genomic Epidemiology of Pseudomonas aeruginosa Sequence Type 111.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Michelle Lowe
Marleen M Kock
Jennifer Coetzee
Ebrahim Hoosien
Gisele Peirano
Kathy-Ann Strydom
Marthie M Ehlers
Nontombi M Mbelle
Elena Shashkina
David B Haslam
Puneet Dhawan
Robert J Donnelly
Liang Chen
Barry N Kreiswirth
Johann D D Pitout
Rutgers, The State University of New Jersey · USNational Health Laboratory Service · ZAUniversity of Pretoria · ZACincinnati Children's Hospital Medical Center · USRutgers New Jersey Medical SchoolUniversity of Calgary · CA

Funding

The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Dissecting the molecular targets to overcome beta-lactam resistance in M. abscessus complexR01AI141805 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2019 to 2026
$5.1M
Genomic variation in epidemic carbapenem-resistant K.pneumoniaeR21AI117338 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHEN, LIANG · 2016 to 2017
$437k
NIAID NIH HHS R01 AI090155NIAID NIH HHS R21 AI117338
6 · The paper itself

Abstract

Klebsiella pneumoniae sequence type (ST) 307 is an emerging global antimicrobial drug-resistant clone. We used whole-genome sequencing and PCR to characterize K. pneumoniae ST307 with oxacillinase (OXA) 181 carbapenemase across several private hospitals in South Africa during 2014-2016. The South Africa ST307 belonged to a different clade (clade VI) with unique genomic characteristics when compared with global ST307 (clades I-V). Bayesian evolution analysis showed that clade VI emerged around March 2013 in Gauteng Province, South Africa, and then evolved during 2014 into 2 distinct lineages. K. pneumoniae ST307 clade VI with OXA-181 disseminated over a 15-month period within 42 hospitals in 23 cities across 6 northeastern provinces, affecting 350 patients. The rapid expansion of ST307 was most likely due to intrahospital, interhospital, intercity, and interprovince movements of patients. This study highlights the importance of molecular surveillance for tracking emerging antimicrobial clones.

Indexed as

Bacterial Proteinsbeta-Lactamasesbeta-Lactam ResistanceCommunicable Diseases, EmergingEvolution, MolecularGenome, BacterialHumansKlebsiella InfectionsKlebsiella pneumoniaeMolecular EpidemiologyPhylogenySouth AfricaBacterial Proteinsbeta-Lactamasesantimicrobial resistancebacteriacarbapenemasesEnterobacteriaceaegenomic surveillanceKlebsiella pneumoniaeoutbreaksequence typeSouth AfricaST307

Identifiers

PMID30882333
PMCPMC6433043
OpenAlexW2918728543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.