Evidence map›Paper›PMID 30882234›Full record

Trial reportCirculation2019

Prophylactic Use of Implantable Cardioverter-Defibrillators in the Prevention of Sudden Cardiac Death in Dialysis Patients.

J Wouter Jukema, Rohit J Timal, Joris I Rotmans, Liselotte C R Hensen, Maurits S Buiten, Mihaly K de Bie, Hein Putter, Aeilko H Zwinderman, Lieselot van Erven, M Jacqueline Krol-van Straaten and 8 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

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  11. Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

J Wouter JukemaDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Rohit J TimalDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Joris I RotmansDepartment of Internal Medicine (J.I.R., T.J.R.), Leiden University Medical Center, The Netherlands.
Liselotte C R HensenDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Maurits S BuitenDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Mihaly K de BieDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Hein PutterDepartment of Biomedical Data Sciences (H.P.), Leiden University Medical Center, The Netherlands.
Aeilko H ZwindermanDepartment of Medical Statistics, Academic Medical Center, Amsterdam, The Netherlands (A.H.Z.).
Lieselot van ErvenDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
M Jacqueline Krol-van StraatenDepartment of Internal Medicine, Haga Hospital, The Hague, The Netherlands (M.J.K.v.S.).
Nienke HommesDepartment of Internal Medicine, Haaglanden Medisch Centrum, The Hague, The Netherlands (N.H.).
Bas GabreëlsDepartment of Internal Medicine, Alrijne Ziekenhuis, Leiderdorp, The Netherlands (B.G.).
Wim van DorpDepartment of Internal Medicine, Spaarne Gasthuis, Haarlem, The Netherlands (W.v.D.).
Bastiaan van DamDepartment of Internal Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands (B.v.D.).
Charles A HerzogDepartment of Internal Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis (C.A.H.).
Martin J SchalijDepartment of Cardiology (J.W.J., R.J.T., L.C.R.H., M.S.B., M.K.d.B., L.v.E., M.J.S.), Leiden University Medical Center, The Netherlands.
Ton J RabelinkDepartment of Internal Medicine (J.I.R., T.J.R.), Leiden University Medical Center, The Netherlands.
ICD2 Trial Investigators
Leiden University Medical Center · NLAlrijne Ziekenhuis · NLAmsterdam UMC Location University of Amsterdam · NLHaga Hospital · NLHennepin County Medical Center · USMedisch Centrum Haaglanden · NLNoordwest Ziekenhuisgroep · NLSpaarne Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with end-stage renal disease who are undergoing dialysis are reported to be at high risk of sudden cardiac death (SCD), and to date, no therapy has been shown to be effective in reducing this risk. The feasibility and value of prophylactic implantable cardioverter-defibrillator (ICD) implantation to prevent SCD is uncertain.

methodsWe conducted the ICD2 trial (Implantable Cardioverter-Defibrillator in Dialysis Patients), a prospective, randomized, controlled study investigating the value and safety of ICD implantation to prevent SCD in 200 patients on dialysis with a left ventricular ejection fraction ≥35%, after adequate screening and optimization of other treatments. The primary end point was SCD. Secondary end points were all-cause mortality and ICD-related complications.

resultsThe trial was stopped as per the recommendation of the data and safety monitoring board for futility reasons after inclusion of 188 patients, 97 in the ICD group and 91 in the control group. The median duration of follow-up was 6.8 years (interquartile range, 3.8-8.8 years). SCD occurred in 19 of 188 cases (10.1%), 11 of 97 in the ICD group and 8 of 91 in the control group. The cumulative SCD incidence at 5 years was 9.7% (95% CI, 3.3%-16.2%) in the ICD group and 7.9% (95% CI, 1.7-14.0%) in the control group, resulting in a hazard ratio of 1.32 (95% CI, 0.53-3.29; P=0.55). Overall, 99 of 188 patients died (52.7%), 52 in the ICD group and 47 in the control group. Five-year survival probability was 50.6% (95% CI, 39.8%-61.5%) in the ICD group and 54.5% (95% CI, 43.0-66.0%) in the control group, resulting in a hazard ratio of 1.02 (95% CI, 0.69-1.52; P=0.92). Among 80 patients who received an ICD, 25 adverse events related to ICD implantation occurred.

conclusionsIn a well-screened and well-treated population undergoing dialysis, prophylactic ICD therapy did not reduce the rate of SCD or all-cause mortality, which remained high. CLINICAL

trial registrationURL: http://www.controlled-trials.com . Unique identifier: ISRCTN20479861.

Indexed as

Defibrillators, ImplantableRenal DialysisAgedAged, 80 and overDeath, Sudden, CardiacEarly Termination of Clinical TrialsElectric CountershockFemaleHeart FailureHumansKidney Failure, ChronicMaleMedical FutilityMiddle AgedNetherlandsProspective Studiesdialysisend-stage renal diseaseimplantable cardioverter-defibrillatorsudden cardiac death

Identifiers

PMID30882234
OpenAlexW2953298463

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.